The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil
Objective: To determine clinical outcomes and mortality risk factors related to mental disorders in a cohort of hospitalized patients with Covid-19 in Brazil. Methods: This retrospective cohort study used a Brazilian database called the Sistema de Vigilância Epidemiológica da Gripe (Influenza Epid...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2024-10-01
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| Series: | Brazilian Journal of Psychiatry |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462024000100224&lng=en&tlng=en |
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| _version_ | 1850212025914884096 |
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| author | Fabrício Emanuel Soares de Oliveira Samuel Trezena Daniella Reis Barbosa Martelli Maria Christina L. Oliveira Enrico A. Colosimo Hercílio Martelli Júnior Eduardo A. Oliveira |
| author_facet | Fabrício Emanuel Soares de Oliveira Samuel Trezena Daniella Reis Barbosa Martelli Maria Christina L. Oliveira Enrico A. Colosimo Hercílio Martelli Júnior Eduardo A. Oliveira |
| author_sort | Fabrício Emanuel Soares de Oliveira |
| collection | DOAJ |
| description | Objective: To determine clinical outcomes and mortality risk factors related to mental disorders in a cohort of hospitalized patients with Covid-19 in Brazil. Methods: This retrospective cohort study used a Brazilian database called the Sistema de Vigilância Epidemiológica da Gripe (Influenza Epidemiological Surveillance System) to analyze patients aged ≥ 18 years who were hospitalized with Covid-19 between 2020 and 2022. The exposure of interest was mental disorders (anxiety, depression, schizophrenia, and bipolar disorder) identified through self-report. The primary outcome was in-hospital mortality. Covariates included demographic and clinical characteristics. Descriptive statistics, t-tests, chi-square tests, and binary logistic regression were used to analyze the data. Results: A cohort of 2,124,285 patients was included in the analysis, with 23,246 individuals (1.1%) self-reporting mental disorders, of which depression was the most prevalent (52.3%). The mortality rate of patients with mental disorders was 30.8%. Age, sex, region, dyspnea, low oxygen saturation, and comorbidities were associated with a higher mortality risk, as was schizophrenia (adjusted OR: 1.68; 95%CI 1.54-1.81). Conclusions: Individuals with schizophrenia had a greater likelihood of Covid-19-related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on Covid-19 mortality. |
| format | Article |
| id | doaj-art-ff7fb8e5b48d48b285f33f35a24ab9e9 |
| institution | OA Journals |
| issn | 1809-452X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj-art-ff7fb8e5b48d48b285f33f35a24ab9e92025-08-20T02:09:25ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2024-10-014610.47626/1516-4446-2024-3540The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in BrazilFabrício Emanuel Soares de Oliveirahttps://orcid.org/0000-0003-0164-1179Samuel Trezenahttps://orcid.org/0000-0002-4217-1276Daniella Reis Barbosa Martellihttps://orcid.org/0000-0002-7497-6052Maria Christina L. Oliveirahttps://orcid.org/0000-0002-2511-6769Enrico A. Colosimohttps://orcid.org/0000-0001-8705-4674Hercílio Martelli Júniorhttps://orcid.org/0000-0001-9691-2802Eduardo A. Oliveirahttps://orcid.org/0000-0002-5642-7164 Objective: To determine clinical outcomes and mortality risk factors related to mental disorders in a cohort of hospitalized patients with Covid-19 in Brazil. Methods: This retrospective cohort study used a Brazilian database called the Sistema de Vigilância Epidemiológica da Gripe (Influenza Epidemiological Surveillance System) to analyze patients aged ≥ 18 years who were hospitalized with Covid-19 between 2020 and 2022. The exposure of interest was mental disorders (anxiety, depression, schizophrenia, and bipolar disorder) identified through self-report. The primary outcome was in-hospital mortality. Covariates included demographic and clinical characteristics. Descriptive statistics, t-tests, chi-square tests, and binary logistic regression were used to analyze the data. Results: A cohort of 2,124,285 patients was included in the analysis, with 23,246 individuals (1.1%) self-reporting mental disorders, of which depression was the most prevalent (52.3%). The mortality rate of patients with mental disorders was 30.8%. Age, sex, region, dyspnea, low oxygen saturation, and comorbidities were associated with a higher mortality risk, as was schizophrenia (adjusted OR: 1.68; 95%CI 1.54-1.81). Conclusions: Individuals with schizophrenia had a greater likelihood of Covid-19-related death than those without mental health conditions. These findings underscore the significant effect of serious mental disorders on Covid-19 mortality.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462024000100224&lng=en&tlng=enMental disordersmental healthCovid-19mortalityschizophrenia |
| spellingShingle | Fabrício Emanuel Soares de Oliveira Samuel Trezena Daniella Reis Barbosa Martelli Maria Christina L. Oliveira Enrico A. Colosimo Hercílio Martelli Júnior Eduardo A. Oliveira The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil Brazilian Journal of Psychiatry Mental disorders mental health Covid-19 mortality schizophrenia |
| title | The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil |
| title_full | The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil |
| title_fullStr | The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil |
| title_full_unstemmed | The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil |
| title_short | The association between schizophrenia and increased Covid-19 mortality in a cohort of over 2 million people in Brazil |
| title_sort | association between schizophrenia and increased covid 19 mortality in a cohort of over 2 million people in brazil |
| topic | Mental disorders mental health Covid-19 mortality schizophrenia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462024000100224&lng=en&tlng=en |
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