Emerging West African Genotype Chikungunya Virus in Mosquito Virome
We studied the viromes of three dominant mosquito species in Wenzhou, a coastal city in Zhejiang Province, using metavirome sequencing, with 18 viral families identified. Viral sequences were verified by RT-PCR. The JEV E gene was most closely related to the 1988 Korean strain. DENV sequences were m...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2024.2444686 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846110652115976192 |
|---|---|
| author | Pengpeng Xiao Yujia Hao Yuge Yuan Wenzhou Ma Yiquan Li He Zhang Nan Li |
| author_facet | Pengpeng Xiao Yujia Hao Yuge Yuan Wenzhou Ma Yiquan Li He Zhang Nan Li |
| author_sort | Pengpeng Xiao |
| collection | DOAJ |
| description | We studied the viromes of three dominant mosquito species in Wenzhou, a coastal city in Zhejiang Province, using metavirome sequencing, with 18 viral families identified. Viral sequences were verified by RT-PCR. The JEV E gene was most closely related to the 1988 Korean strain. DENV sequences were most closely related to the 1997 Australian strain. CHIKV-E1-1 was most closely related to the 1983 Senegal strain and belonged to West African genotype CHIKV. Remarkably, this is the first time that a West African genotype of CHIKV has been detected in Zhejiang Province. Mutations in the CHIKV-E1-1 protein A226V may increase infectivity in Ae. albopictus. Three non-conservative mutations of CHIKV-E1-1 (D45H, D70H and V290D) may have an impact on the function. In conclusion, our study reveals the diversity of mosquito-borne viruses and potential emerging outbreaks in the southeast coastal region of China, providing new perspectives for mining the ecological characterization of other important arboviruses. |
| format | Article |
| id | doaj-art-ff7043207dba474a946f33a8841b1cd3 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-ff7043207dba474a946f33a8841b1cd32024-12-23T20:57:22ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2024.2444686Emerging West African Genotype Chikungunya Virus in Mosquito ViromePengpeng Xiao0Yujia Hao1Yuge Yuan2Wenzhou Ma3Yiquan Li4He Zhang5Nan Li6Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWe studied the viromes of three dominant mosquito species in Wenzhou, a coastal city in Zhejiang Province, using metavirome sequencing, with 18 viral families identified. Viral sequences were verified by RT-PCR. The JEV E gene was most closely related to the 1988 Korean strain. DENV sequences were most closely related to the 1997 Australian strain. CHIKV-E1-1 was most closely related to the 1983 Senegal strain and belonged to West African genotype CHIKV. Remarkably, this is the first time that a West African genotype of CHIKV has been detected in Zhejiang Province. Mutations in the CHIKV-E1-1 protein A226V may increase infectivity in Ae. albopictus. Three non-conservative mutations of CHIKV-E1-1 (D45H, D70H and V290D) may have an impact on the function. In conclusion, our study reveals the diversity of mosquito-borne viruses and potential emerging outbreaks in the southeast coastal region of China, providing new perspectives for mining the ecological characterization of other important arboviruses.https://www.tandfonline.com/doi/10.1080/21505594.2024.2444686ViromemosquitoChikungunya virusphylogenetic analysisvirus variation |
| spellingShingle | Pengpeng Xiao Yujia Hao Yuge Yuan Wenzhou Ma Yiquan Li He Zhang Nan Li Emerging West African Genotype Chikungunya Virus in Mosquito Virome Virulence Virome mosquito Chikungunya virus phylogenetic analysis virus variation |
| title | Emerging West African Genotype Chikungunya Virus in Mosquito Virome |
| title_full | Emerging West African Genotype Chikungunya Virus in Mosquito Virome |
| title_fullStr | Emerging West African Genotype Chikungunya Virus in Mosquito Virome |
| title_full_unstemmed | Emerging West African Genotype Chikungunya Virus in Mosquito Virome |
| title_short | Emerging West African Genotype Chikungunya Virus in Mosquito Virome |
| title_sort | emerging west african genotype chikungunya virus in mosquito virome |
| topic | Virome mosquito Chikungunya virus phylogenetic analysis virus variation |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2024.2444686 |
| work_keys_str_mv | AT pengpengxiao emergingwestafricangenotypechikungunyavirusinmosquitovirome AT yujiahao emergingwestafricangenotypechikungunyavirusinmosquitovirome AT yugeyuan emergingwestafricangenotypechikungunyavirusinmosquitovirome AT wenzhouma emergingwestafricangenotypechikungunyavirusinmosquitovirome AT yiquanli emergingwestafricangenotypechikungunyavirusinmosquitovirome AT hezhang emergingwestafricangenotypechikungunyavirusinmosquitovirome AT nanli emergingwestafricangenotypechikungunyavirusinmosquitovirome |