Multicentre, randomised, open-label, phase IV–III study to evaluate the efficacy of cloxacillin plus fosfomycin versus cloxacillin alone in adult patients with methicillin-susceptible Staphylococcus aureus bacteraemia: study protocol for the SAFO trial

Multicentre, randomised, open-label, phase IV–III study to evaluate the efficacy of cloxacillin plus fosfomycin versus cloxacillin alone in adult patients with methicillin-susceptible Staphylococcus aureus bacteraemia: study protocol for the SAFO trial

Introduction Methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia is a frequent condition, with high mortality rates. There is a growing interest in identifying new therapeutic regimens able to reduce therapeutic failure and mortality observed with the standard of care of beta-lactam mon...

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Main Authors: Joaquin López-contreras, Josep M Miró, Cristian Tebe, Jordi Carratalà, Guillermo Cuervo, Oriol Gasch, Miquel Pujol, Esther Calbo, Yolanda Meije, Ariadna Padullés, Sebastian Videla, José M Aguado, Francesca Gioia, Luis Eduardo López-Cortés, Sara Grillo, Rafael San-Juan, Silvia Gomez-Zorrilla, Aina Gomila-Grange, Simona Iftimie, Graciano Garcia-Pardo, Lucía Boix-Palop, Isabel Oriol, Alfredo Jover-Sáenz, Gorane Euba, Malen Aguirregabiria, Maria Jose Garcia-Pais, Jose Ramón Paño, Maria Luisa Pedro-Botet, Rosa Maria Benítez, Maria Teresa Pérez-Rodríguez, Maria Belén Loeches-Yagüe, Gertrudis Horna, Damaris Berbel, Maria Ángeles Domínguez, Sara Cobo, Pilar Hereu, Natàlia Pallarés
Format: Article
Language:English
Published: BMJ Publishing Group 2021-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/8/e051208.full
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