Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population
Objective ST segment elevation myocardial infarction (STEMI) is associated with significant mortality leading to loss of productive life years, especially in younger patients. This study aims to compare the characteristics and outcomes of young versus older patients with STEMI undergoing primary per...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-02-01
|
| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/8/1/e001437.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846170641468751872 |
|---|---|
| author | Kian Keong Poh William Kristanto Benjamin WL Tung Zhe Yan Ng Kalyar Win Saw Siew-Pang Chan Winnie Sia Koo Hui Chan Mark Chan William Kong Ronald Lee Joshua P Loh Adrian F Low Edgar Tay Huay Cheem Tan Tiong-Cheng Yeo Poay Huan Loh |
| author_facet | Kian Keong Poh William Kristanto Benjamin WL Tung Zhe Yan Ng Kalyar Win Saw Siew-Pang Chan Winnie Sia Koo Hui Chan Mark Chan William Kong Ronald Lee Joshua P Loh Adrian F Low Edgar Tay Huay Cheem Tan Tiong-Cheng Yeo Poay Huan Loh |
| author_sort | Kian Keong Poh |
| collection | DOAJ |
| description | Objective ST segment elevation myocardial infarction (STEMI) is associated with significant mortality leading to loss of productive life years, especially in younger patients. This study aims to compare the characteristics and outcomes of young versus older patients with STEMI undergoing primary percutaneous coronary intervention (PPCI) to help focus public health efforts in STEMI prevention.Methods Data from the Coronary Care Unit database of the National University Hospital, Singapore from July 2015 to June 2019 were reviewed. Patients were divided into young (<50 years old) or older (≥50 years old) groups.Results Of the 1818 consecutive patients with STEMI who underwent PPCI, 465 (25.6%) were <50 years old. Young compared with older patients were more likely to be male, current smokers, of Indian ethnicity, have family history of ischaemic heart disease (IHD) and had lower 1 year mortality (3.4% vs 10.4%, p<0.0001). Although diabetes, hypertension or dyslipidaemia was less common among young patients, the prevalence of having any one of these risk factors was high in the range of 28% to 38%. Age was an independent predictor of mortality in the older but not younger patients with STEMI, and diabetes showed a trend towards mortality in both groups.Conclusion Young patients with STEMI are more often smokers, of Indian ethnicity and had family history of IHD, although cardiometabolic risk factors are also prevalent. Mortality is lower, but not negligible, among the young patients with STEMI. Public health efforts are needed to reduce the prevalence of these risk factors among the constitutionally susceptible population. |
| format | Article |
| id | doaj-art-ff6a8983f5934ccdbb38a12460e87f3a |
| institution | Kabale University |
| issn | 2053-3624 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj-art-ff6a8983f5934ccdbb38a12460e87f3a2024-11-11T14:35:07ZengBMJ Publishing GroupOpen Heart2053-36242021-02-018110.1136/openhrt-2020-001437Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian populationKian Keong Poh0William Kristanto1Benjamin WL Tung2Zhe Yan Ng3Kalyar Win Saw4Siew-Pang Chan5Winnie Sia6Koo Hui Chan7Mark Chan8William Kong9Ronald Lee10Joshua P Loh11Adrian F Low12Edgar Tay13Huay Cheem Tan14Tiong-Cheng Yeo15Poay Huan Loh16Department of Cardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeNational University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, SingaporeCardiology, National University Heart Centre, Singapore5 Asian Heart & Vascular Centre, Mount Elizabeth Novena Hospital, SingaporeCardiology, National University Heart Centre, Singapore4 Department of Cardiology, National University Heart Centre Singapore, National University Health System, SingaporeDepartment of Cardiology, Singapore Health Service, SingaporeObjective ST segment elevation myocardial infarction (STEMI) is associated with significant mortality leading to loss of productive life years, especially in younger patients. This study aims to compare the characteristics and outcomes of young versus older patients with STEMI undergoing primary percutaneous coronary intervention (PPCI) to help focus public health efforts in STEMI prevention.Methods Data from the Coronary Care Unit database of the National University Hospital, Singapore from July 2015 to June 2019 were reviewed. Patients were divided into young (<50 years old) or older (≥50 years old) groups.Results Of the 1818 consecutive patients with STEMI who underwent PPCI, 465 (25.6%) were <50 years old. Young compared with older patients were more likely to be male, current smokers, of Indian ethnicity, have family history of ischaemic heart disease (IHD) and had lower 1 year mortality (3.4% vs 10.4%, p<0.0001). Although diabetes, hypertension or dyslipidaemia was less common among young patients, the prevalence of having any one of these risk factors was high in the range of 28% to 38%. Age was an independent predictor of mortality in the older but not younger patients with STEMI, and diabetes showed a trend towards mortality in both groups.Conclusion Young patients with STEMI are more often smokers, of Indian ethnicity and had family history of IHD, although cardiometabolic risk factors are also prevalent. Mortality is lower, but not negligible, among the young patients with STEMI. Public health efforts are needed to reduce the prevalence of these risk factors among the constitutionally susceptible population.https://openheart.bmj.com/content/8/1/e001437.full |
| spellingShingle | Kian Keong Poh William Kristanto Benjamin WL Tung Zhe Yan Ng Kalyar Win Saw Siew-Pang Chan Winnie Sia Koo Hui Chan Mark Chan William Kong Ronald Lee Joshua P Loh Adrian F Low Edgar Tay Huay Cheem Tan Tiong-Cheng Yeo Poay Huan Loh Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population Open Heart |
| title | Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population |
| title_full | Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population |
| title_fullStr | Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population |
| title_full_unstemmed | Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population |
| title_short | Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population |
| title_sort | characteristics and outcomes of young patients with st segment elevation myocardial infarction undergoing primary percutaneous coronary intervention retrospective analysis in a multiethnic asian population |
| url | https://openheart.bmj.com/content/8/1/e001437.full |
| work_keys_str_mv | AT kiankeongpoh characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT williamkristanto characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT benjaminwltung characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT zheyanng characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT kalyarwinsaw characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT siewpangchan characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT winniesia characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT koohuichan characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT markchan characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT williamkong characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT ronaldlee characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT joshuaploh characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT adrianflow characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT edgartay characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT huaycheemtan characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT tiongchengyeo characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation AT poayhuanloh characteristicsandoutcomesofyoungpatientswithstsegmentelevationmyocardialinfarctionundergoingprimarypercutaneouscoronaryinterventionretrospectiveanalysisinamultiethnicasianpopulation |