Near-infrared light activatable chemically induced CRISPR system

Abstract The biggest challenge in using CRISPR technologies, which limits their widespread application in medicine, is off-target effects. These effects could, in principle, be minimized by ensuring that CRISPR is activated primarily in the targeted cells, thereby reducing the likelihood of unintend...

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Bibliographic Details
Main Authors: Lei Zhang, Xuejun Zhang, Le Qiu, Song Mao, Jia Sheng, Liming Chen, Umar Khan, Paul K. Upputuri, Yuri N. Zakharov, Mark F. Coughlan, Lev T. Perelman
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Light: Science & Applications
Online Access:https://doi.org/10.1038/s41377-025-01917-8
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