Metformin: A Potential Drug for COVID-19
Metformin is an old drug, of plant origin, primarily used in the treatment of type 2 diabetes. The main mechanism of its action is mediated through adenosine monophosphate (AMP) kinase. Though the main action of metformin is to inhibit hepatic gluconeogenesis, it is also known to increase insulin se...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2024-04-01
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| Series: | Indian Journal of Medical Biochemistry |
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| Online Access: | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0230 |
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| author | Anjali Devi Bettadapura Shankara Rao Sujatha Puttalingaiah Ananth B Koushik Jadeppa Gowda |
| author_facet | Anjali Devi Bettadapura Shankara Rao Sujatha Puttalingaiah Ananth B Koushik Jadeppa Gowda |
| author_sort | Anjali Devi Bettadapura Shankara Rao |
| collection | DOAJ |
| description | Metformin is an old drug, of plant origin, primarily used in the treatment of type 2 diabetes. The main mechanism of its action is mediated through adenosine monophosphate (AMP) kinase. Though the main action of metformin is to inhibit hepatic gluconeogenesis, it is also known to increase insulin sensitivity and is used in the treatment of obesity and polycystic ovarian disease. Its varied actions on coronavirus infections, by inhibiting virus entry, preventing cytokine storm, boosting immunity by altering the gut microbiota, and decreasing virulence by inducing autophagy makes it an ideal candidate for treating coronavirus disease-2019 (COVID-19). The only serious side effect of metformin is lactic acidosis, confined to a few patients. The drug is already approved by the US Food and Drug Administration (FDA) and thus repurposing it in COVID-19 patients may be beneficial.
Metformin is a drug, approved by FDA for treating diabetes mellitus with very few side effects. It is inexpensive and is known to exhibit anti-COVID-19 actions. It has also proven to be effective in treating PCOS and obesity. Thus, it has all the potential to treat COVID-19. |
| format | Article |
| id | doaj-art-ff4b799072ac4e5bb31f21e479546614 |
| institution | Kabale University |
| issn | 2456-5164 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Medical Biochemistry |
| spelling | doaj-art-ff4b799072ac4e5bb31f21e4795466142025-01-03T07:48:12ZengJaypee Brothers Medical PublisherIndian Journal of Medical Biochemistry2456-51642024-04-0128129010.5005/jp-journals-10054-02301Metformin: A Potential Drug for COVID-19Anjali Devi Bettadapura Shankara Rao0https://orcid.org/0000-0002-0423-9313Sujatha Puttalingaiah1https://orcid.org/0000-0003-3290-2247Ananth B Koushik2https://orcid.org/0009-0002-4580-8209Jadeppa Gowda3https://orcid.org/0009-0001-9490-3192Anjali Devi Bettadapura Shankara Rao, Department of Biochemistry, JSS Medical College, Mysuru, Karnataka, India, Phone: +91 9886787981Department of Biochemistry, JSS Medical College, Mysuru, Karnataka, IndiaDepartment of Biochemistry, JSS Medical College, Mysuru, Karnataka, IndiaDepartment of Biochemistry, JSS Medical College, Mysuru, Karnataka, IndiaMetformin is an old drug, of plant origin, primarily used in the treatment of type 2 diabetes. The main mechanism of its action is mediated through adenosine monophosphate (AMP) kinase. Though the main action of metformin is to inhibit hepatic gluconeogenesis, it is also known to increase insulin sensitivity and is used in the treatment of obesity and polycystic ovarian disease. Its varied actions on coronavirus infections, by inhibiting virus entry, preventing cytokine storm, boosting immunity by altering the gut microbiota, and decreasing virulence by inducing autophagy makes it an ideal candidate for treating coronavirus disease-2019 (COVID-19). The only serious side effect of metformin is lactic acidosis, confined to a few patients. The drug is already approved by the US Food and Drug Administration (FDA) and thus repurposing it in COVID-19 patients may be beneficial. Metformin is a drug, approved by FDA for treating diabetes mellitus with very few side effects. It is inexpensive and is known to exhibit anti-COVID-19 actions. It has also proven to be effective in treating PCOS and obesity. Thus, it has all the potential to treat COVID-19.https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0230adenosine monophosphate kinaseangiotensin-converting enzyme 2coronavirus disease-2019mammalian target of rapamycinmetforminsevere acute respiratory syndrome |
| spellingShingle | Anjali Devi Bettadapura Shankara Rao Sujatha Puttalingaiah Ananth B Koushik Jadeppa Gowda Metformin: A Potential Drug for COVID-19 Indian Journal of Medical Biochemistry adenosine monophosphate kinase angiotensin-converting enzyme 2 coronavirus disease-2019 mammalian target of rapamycin metformin severe acute respiratory syndrome |
| title | Metformin: A Potential Drug for COVID-19 |
| title_full | Metformin: A Potential Drug for COVID-19 |
| title_fullStr | Metformin: A Potential Drug for COVID-19 |
| title_full_unstemmed | Metformin: A Potential Drug for COVID-19 |
| title_short | Metformin: A Potential Drug for COVID-19 |
| title_sort | metformin a potential drug for covid 19 |
| topic | adenosine monophosphate kinase angiotensin-converting enzyme 2 coronavirus disease-2019 mammalian target of rapamycin metformin severe acute respiratory syndrome |
| url | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0230 |
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