Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES
ObjectiveThe dietary index for gut microbiota. DI-GM is an innovative metric designed to capture the diversity of the gut microbiome, yet its association with constipation remains unstudied.MethodsIn this cross-sectional study, 11,405 adults aged 20 and older were selected from the National Health a...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1529373/full |
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| author | Zhuhui Zhang Chunlu Bi Runsheng Wu Muwen Qu |
| author_facet | Zhuhui Zhang Chunlu Bi Runsheng Wu Muwen Qu |
| author_sort | Zhuhui Zhang |
| collection | DOAJ |
| description | ObjectiveThe dietary index for gut microbiota. DI-GM is an innovative metric designed to capture the diversity of the gut microbiome, yet its association with constipation remains unstudied.MethodsIn this cross-sectional study, 11,405 adults aged 20 and older were selected from the National Health and Nutrition Examination Survey 2005–2010 for the sample. Constipation was defined as fewer than three defecation frequencies per week using bowel health questionnaire (BHQ). Fewer than three bowel movements per week were considered as constipation by Bowel Health Questionnaire (BHQ). DI-GM was derived from dietary recall data, including avocado, broccoli, chickpeas, coffee, cranberries, fermented dairy, fiber, green tea, soybean and whole grains as beneficial elements, red meat, processed meat, refined grains, and high fat as detrimental components. Multivariable weighted logistic was employed to investigate the association of DI-GM with constipation. Secondary analyses included subgroup analyses, restricted cubic spline (RCS), and multiple imputation.ResultsA higher DI-GM and beneficial gut microbiota score were associated with a lower prevalence of constipation (DI-GM: OR = 0.82, 95% CI = 0.75, 0.90; beneficial gut microbiota score: OR = 0.77, 95% CI = 0.67, 0.89). After grouping DI-GM, in the fully adjusted model, participants with DI-GM ≥ 6 were significantly negatively correlated with both the prevalence of constipation (OR = 0.48, 95% CI = 0.33, 0.71). RCS indicated a non-linear relationship between DI-GM and constipation. Subgroup analyses by age, sex and common complications showed no statistically significant interactions (p > 0.05).ConclusionThe newly proposed DI-GM was inversely related with the prevalence of constipation. When treating patients with constipation, it is necessary for clinicians to provide timely and effective dietary interventions incorporating the DI-GM for patients with constipation to avoid further deterioration of the condition. |
| format | Article |
| id | doaj-art-ff4938542195468d9ef4923eea4b62ef |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-ff4938542195468d9ef4923eea4b62ef2025-01-17T05:10:40ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15293731529373Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANESZhuhui Zhang0Chunlu Bi1Runsheng Wu2Muwen Qu3Department of Anorectal Surgery, Guang’ Anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Anorectal Surgery, Shenzhen Traditional Chinese Medicine Anorectal Hospital (Futian), Shenzhen, ChinaDepartment of Urology, Shenzhen Pingle Orthopedics Hospital, Shenzhen, Guangdong, ChinaDepartment of Anorectal Surgery, Guang’ Anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaObjectiveThe dietary index for gut microbiota. DI-GM is an innovative metric designed to capture the diversity of the gut microbiome, yet its association with constipation remains unstudied.MethodsIn this cross-sectional study, 11,405 adults aged 20 and older were selected from the National Health and Nutrition Examination Survey 2005–2010 for the sample. Constipation was defined as fewer than three defecation frequencies per week using bowel health questionnaire (BHQ). Fewer than three bowel movements per week were considered as constipation by Bowel Health Questionnaire (BHQ). DI-GM was derived from dietary recall data, including avocado, broccoli, chickpeas, coffee, cranberries, fermented dairy, fiber, green tea, soybean and whole grains as beneficial elements, red meat, processed meat, refined grains, and high fat as detrimental components. Multivariable weighted logistic was employed to investigate the association of DI-GM with constipation. Secondary analyses included subgroup analyses, restricted cubic spline (RCS), and multiple imputation.ResultsA higher DI-GM and beneficial gut microbiota score were associated with a lower prevalence of constipation (DI-GM: OR = 0.82, 95% CI = 0.75, 0.90; beneficial gut microbiota score: OR = 0.77, 95% CI = 0.67, 0.89). After grouping DI-GM, in the fully adjusted model, participants with DI-GM ≥ 6 were significantly negatively correlated with both the prevalence of constipation (OR = 0.48, 95% CI = 0.33, 0.71). RCS indicated a non-linear relationship between DI-GM and constipation. Subgroup analyses by age, sex and common complications showed no statistically significant interactions (p > 0.05).ConclusionThe newly proposed DI-GM was inversely related with the prevalence of constipation. When treating patients with constipation, it is necessary for clinicians to provide timely and effective dietary interventions incorporating the DI-GM for patients with constipation to avoid further deterioration of the condition.https://www.frontiersin.org/articles/10.3389/fnut.2025.1529373/fullDI-GMconstipationcross-sectional studyNHANESbowel health |
| spellingShingle | Zhuhui Zhang Chunlu Bi Runsheng Wu Muwen Qu Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES Frontiers in Nutrition DI-GM constipation cross-sectional study NHANES bowel health |
| title | Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES |
| title_full | Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES |
| title_fullStr | Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES |
| title_full_unstemmed | Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES |
| title_short | Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES |
| title_sort | association of the newly proposed dietary index for gut microbiota and constipation a cross sectional study from nhanes |
| topic | DI-GM constipation cross-sectional study NHANES bowel health |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1529373/full |
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