Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand
Introduction To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT).Research design and methods Using data from a primary care dataset linked with multiple health r...
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BMJ Publishing Group
2024-12-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/12/6/e004210.full |
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| author | Hang Fu Dahai Yu Zheng Wang Yamei Cai Zhanzheng Zhao David Simmons Karen Pickering John Baker Gerhard Sundborn Richard Cutfield Brandon J Orr-Walker Chengzeng Wang |
| author_facet | Hang Fu Dahai Yu Zheng Wang Yamei Cai Zhanzheng Zhao David Simmons Karen Pickering John Baker Gerhard Sundborn Richard Cutfield Brandon J Orr-Walker Chengzeng Wang |
| author_sort | Hang Fu |
| collection | DOAJ |
| description | Introduction To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT).Research design and methods Using data from a primary care dataset linked with multiple health registries, this longitudinal study analyzed demographics, clinical data, and lifestyle factors of women diagnosed with GDM or IGT, assessing T2D incidence over 25 years, using Cox regression models.Results Women with GDM, especially those over 35 years of Māori ethnicity, or socioeconomic deprivation, exhibited an elevated risk of T2D compared with those with IGT. The first 5 years post partum emerged as a critical window for intervention.Conclusions This study underscores the importance of early, targeted post-GDM interventions to mitigate T2D risk. It highlights the necessity of personalized post-GDM interventions to reduce T2D incidence which consider age, ethnicity, and socioeconomic status to maximize effectiveness. |
| format | Article |
| id | doaj-art-ff3d5c0de4cf42218048184d8f3d6b9a |
| institution | Kabale University |
| issn | 2052-4897 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj-art-ff3d5c0de4cf42218048184d8f3d6b9a2024-12-16T16:00:09ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972024-12-0112610.1136/bmjdrc-2024-004210Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New ZealandHang Fu0Dahai Yu1Zheng Wang2Yamei Cai3Zhanzheng Zhao4David Simmons5Karen Pickering6John Baker7Gerhard Sundborn8Richard Cutfield9Brandon J Orr-Walker10Chengzeng Wang11Institute of Hospital Management of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaHenan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzholu, Henan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzholu, Henan, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzholu, Henan, ChinaTranslational Health Research Institute, Western Sydney University, Sydney, New South Wales, AustraliaDiabetes Foundation Aotearoa, Auckland, New ZealandCounties Manukau District Health Board, Auckland, New ZealandUniversity of Auckland, Auckland, New ZealandDiabetes Foundation Aotearoa, Auckland, New ZealandCounties Manukau District Health Board, Auckland, New ZealandHenan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaIntroduction To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT).Research design and methods Using data from a primary care dataset linked with multiple health registries, this longitudinal study analyzed demographics, clinical data, and lifestyle factors of women diagnosed with GDM or IGT, assessing T2D incidence over 25 years, using Cox regression models.Results Women with GDM, especially those over 35 years of Māori ethnicity, or socioeconomic deprivation, exhibited an elevated risk of T2D compared with those with IGT. The first 5 years post partum emerged as a critical window for intervention.Conclusions This study underscores the importance of early, targeted post-GDM interventions to mitigate T2D risk. It highlights the necessity of personalized post-GDM interventions to reduce T2D incidence which consider age, ethnicity, and socioeconomic status to maximize effectiveness.https://drc.bmj.com/content/12/6/e004210.full |
| spellingShingle | Hang Fu Dahai Yu Zheng Wang Yamei Cai Zhanzheng Zhao David Simmons Karen Pickering John Baker Gerhard Sundborn Richard Cutfield Brandon J Orr-Walker Chengzeng Wang Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand BMJ Open Diabetes Research & Care |
| title | Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand |
| title_full | Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand |
| title_fullStr | Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand |
| title_full_unstemmed | Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand |
| title_short | Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand |
| title_sort | comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades a multiethnic prospective cohort in new zealand |
| url | https://drc.bmj.com/content/12/6/e004210.full |
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