Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients
Background The study investigates the relationship between Plasminogen activator inhibitor-1 (PAI-1) levels and the progression of diabetic nephropathy (DN). The fibrinolytic system is impaired in type 2 diabetes mellitus (DM), leading to elevated PAI-1 levels, increasing the potential for renal fib...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-07-01
|
| Series: | Al-Azhar Assiut Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/azmj.azmj_22_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525344003162112 |
|---|---|
| author | El-Saeid M.E.-S. El-Bawab Mostafa M.M. Alomairi Ashraf M. El- Kabeer Sayed F.A. Abd-Allah |
| author_facet | El-Saeid M.E.-S. El-Bawab Mostafa M.M. Alomairi Ashraf M. El- Kabeer Sayed F.A. Abd-Allah |
| author_sort | El-Saeid M.E.-S. El-Bawab |
| collection | DOAJ |
| description | Background
The study investigates the relationship between Plasminogen activator inhibitor-1 (PAI-1) levels and the progression of diabetic nephropathy (DN). The fibrinolytic system is impaired in type 2 diabetes mellitus (DM), leading to elevated PAI-1 levels, increasing the potential for renal fibrosis and worsening nephropathy.
Patients and methods
The research involved 196 type 2 DM patients and 50 healthy control individuals divided into four groups based on Urinary albumin excretion (UAE).
Results
The diabetic group had significantly higher PAI-1 levels than the control group. The study also found that diabetic patients with macroalbuminuria had higher PAI-1 levels than the control group. Patients with higher UAE and PAI-1 levels had significantly higher serum creatinine concentrations. The study found a significant negative link with creatinine clearance and a significant positive correlation between PAI-1 and serum creatinine and 24-h urine albumin in terms of PAI-1.
Conclusions
There was a notable positive association with the 24-h UAE, suggesting that increases in PAI-1 were linked to a decline in renal function. |
| format | Article |
| id | doaj-art-ff2a7bb1b14b4558a3e97f5c7b7c47f8 |
| institution | Kabale University |
| issn | 1687-1693 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Al-Azhar Assiut Medical Journal |
| spelling | doaj-art-ff2a7bb1b14b4558a3e97f5c7b7c47f82025-01-17T15:28:35ZengWolters Kluwer Medknow PublicationsAl-Azhar Assiut Medical Journal1687-16932023-07-0121317818310.4103/azmj.azmj_22_24Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patientsEl-Saeid M.E.-S. El-BawabMostafa M.M. AlomairiAshraf M. El- KabeerSayed F.A. Abd-AllahBackground The study investigates the relationship between Plasminogen activator inhibitor-1 (PAI-1) levels and the progression of diabetic nephropathy (DN). The fibrinolytic system is impaired in type 2 diabetes mellitus (DM), leading to elevated PAI-1 levels, increasing the potential for renal fibrosis and worsening nephropathy. Patients and methods The research involved 196 type 2 DM patients and 50 healthy control individuals divided into four groups based on Urinary albumin excretion (UAE). Results The diabetic group had significantly higher PAI-1 levels than the control group. The study also found that diabetic patients with macroalbuminuria had higher PAI-1 levels than the control group. Patients with higher UAE and PAI-1 levels had significantly higher serum creatinine concentrations. The study found a significant negative link with creatinine clearance and a significant positive correlation between PAI-1 and serum creatinine and 24-h urine albumin in terms of PAI-1. Conclusions There was a notable positive association with the 24-h UAE, suggesting that increases in PAI-1 were linked to a decline in renal function.https://journals.lww.com/10.4103/azmj.azmj_22_24diabetic nephropathyend-stage renal diseasefibrinolytic systemplasminogen activator inhibitor-1plasminogen activator inhibitor-1renal fibrosistype 2 diabetes mellitus |
| spellingShingle | El-Saeid M.E.-S. El-Bawab Mostafa M.M. Alomairi Ashraf M. El- Kabeer Sayed F.A. Abd-Allah Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients Al-Azhar Assiut Medical Journal diabetic nephropathy end-stage renal disease fibrinolytic system plasminogen activator inhibitor-1 plasminogen activator inhibitor-1 renal fibrosis type 2 diabetes mellitus |
| title | Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients |
| title_full | Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients |
| title_fullStr | Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients |
| title_full_unstemmed | Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients |
| title_short | Plasma plasminogen activator inhibitor-1 as a predictive marker of type 2 diabetic nephropathy in Egyptian patients |
| title_sort | plasma plasminogen activator inhibitor 1 as a predictive marker of type 2 diabetic nephropathy in egyptian patients |
| topic | diabetic nephropathy end-stage renal disease fibrinolytic system plasminogen activator inhibitor-1 plasminogen activator inhibitor-1 renal fibrosis type 2 diabetes mellitus |
| url | https://journals.lww.com/10.4103/azmj.azmj_22_24 |
| work_keys_str_mv | AT elsaeidmeselbawab plasmaplasminogenactivatorinhibitor1asapredictivemarkeroftype2diabeticnephropathyinegyptianpatients AT mostafammalomairi plasmaplasminogenactivatorinhibitor1asapredictivemarkeroftype2diabeticnephropathyinegyptianpatients AT ashrafmelkabeer plasmaplasminogenactivatorinhibitor1asapredictivemarkeroftype2diabeticnephropathyinegyptianpatients AT sayedfaabdallah plasmaplasminogenactivatorinhibitor1asapredictivemarkeroftype2diabeticnephropathyinegyptianpatients |