SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad
Abstract Background Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosi...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10099-4 |
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| author | Koutaya Dezoumbe Oumaima Djarma Andrillene Laure Deutou Wondeu Fatima Abdelrazak Zakaria Sabrina Atturo Nathan Naïbeï Franck J. D. Mennechet Denise Campagna Abdoulaye Boukar Choroma Ahmat Moussa Issa Mahamat Nontegyol Armand Mahamat Idriss Hamad Netalar Honorine Kayanlengar Frederic Adam Adami Moustapha Yanda Mberkissam Daniel Adam Moussa Alim Mahamat Grene Noubaramadji Yamti Suitombaye Amine Akouya Ouchemi Choua Hota Mathieu Djallaye Djimtoïbaye Vittorio Colizzi Giulia Cappelli Takoudjou Dzomo Guy Rodrigue Mahamat Fayiz Abakar Ali Mahamat Moussa |
| author_facet | Koutaya Dezoumbe Oumaima Djarma Andrillene Laure Deutou Wondeu Fatima Abdelrazak Zakaria Sabrina Atturo Nathan Naïbeï Franck J. D. Mennechet Denise Campagna Abdoulaye Boukar Choroma Ahmat Moussa Issa Mahamat Nontegyol Armand Mahamat Idriss Hamad Netalar Honorine Kayanlengar Frederic Adam Adami Moustapha Yanda Mberkissam Daniel Adam Moussa Alim Mahamat Grene Noubaramadji Yamti Suitombaye Amine Akouya Ouchemi Choua Hota Mathieu Djallaye Djimtoïbaye Vittorio Colizzi Giulia Cappelli Takoudjou Dzomo Guy Rodrigue Mahamat Fayiz Abakar Ali Mahamat Moussa |
| author_sort | Koutaya Dezoumbe |
| collection | DOAJ |
| description | Abstract Background Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosis. The high rate of asymptomatic infections reflects the reality of SARS-CoV-2 transmission in Chad. In this study, we estimated the seroprevalence and identified factors associated with SARS-CoV-2 infection. Methods A cross-sectional study was conducted between September 2022 and February 2023. A total of 1,290 plasma samples were collected from outpatient attendees at Health Facilities located in 11 provinces of Chad and tested by ELISA method, for the presence of IgG antibodies to SARS-CoV2 nucleocapsid (N) protein. KoboToolbox was used to gather data from the participants and data were analyzed using STATA 16. Results The overall seroprevalence was 83.0% [95% CI = 81.6%—85.5%], with variations between provinces, ranging from 99.2% [95% CI = 94.0%—100%] in Moundou (Southern Chad) to 46.8% [95% CI = 36.0% -57.1%] in Biltine (Eastern Chad). Factors associated with the seroprevalence included military occupation (OR = 0.37 CI [0.80–1.77] p = 0.025) and age group between 55–64 years (OR = 0.33 CI [0.15–0.72] p = 0.005). While, other factors, such as gender and age were not significantly associated with seroprevalence. Conclusion Our results indicated that, the seroprevalence of COVID-19 in Chad is among the highest in Sub-Saharan Africa. These estimates could guide the response and public health policy decisions, enhancing the management of future outbreaks involving respiratory pathogens. |
| format | Article |
| id | doaj-art-feea47f4f7224d82aef738ae9a4f7315 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-feea47f4f7224d82aef738ae9a4f73152024-11-17T12:11:58ZengBMCBMC Infectious Diseases1471-23342024-11-012411810.1186/s12879-024-10099-4SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in ChadKoutaya Dezoumbe0Oumaima Djarma1Andrillene Laure Deutou Wondeu2Fatima Abdelrazak Zakaria3Sabrina Atturo4Nathan Naïbeï5Franck J. D. Mennechet6Denise Campagna7Abdoulaye Boukar8Choroma Ahmat Moussa9Issa Mahamat10Nontegyol Armand11Mahamat Idriss Hamad12Netalar Honorine13Kayanlengar Frederic14Adam Adami Moustapha15Yanda Mberkissam Daniel16Adam Moussa Alim17Mahamat Grene18Noubaramadji Yamti Suitombaye19Amine Akouya20Ouchemi Choua21Hota Mathieu22Djallaye Djimtoïbaye23Vittorio Colizzi24Giulia Cappelli25Takoudjou Dzomo Guy Rodrigue26Mahamat Fayiz Abakar27Ali Mahamat Moussa28Major Tropical Epidemics Laboratory “LAGET” of the , Good Samaritan University Hospital CentreDepartment of Infectious Diseases, Le Bon Samaritain University, National University Hospital of ReferenceEvangelical University of CameroonInstitut de Recherche en Elevage Pour Le Développement (IRED) FarchaItalian Jesuit Movement and Action for Development Foundation (MAGIS)CAID-Tchad”Pathogenesis and Control of Chronic an Emerging Infections (PCCEI), University of Montpellier, French Blood Establishment (EFS)Institute for Biological Systems (ISB), CNRKing Faycal HospitalAbeché University Hospital LaboratoryPMTCT/HIV Health DistrictProvincial HospitalProvincial HospitalProvincial HospitalProvincial HospitalProvincial HospitalProvincial HospitalProvincial HospitalProvincial HospitalMajor Tropical Epidemics Laboratory “LAGET” of the , Good Samaritan University Hospital CentreMajor Tropical Epidemics Laboratory “LAGET” of the , Good Samaritan University Hospital CentreFaculty of Human Health Sciences, N’Djamena UniversityDepartment of Laboratories, Ministry of Public HealthMajor Tropical Epidemics Laboratory “LAGET” of the , Good Samaritan University Hospital CentreEvangelical University of CameroonInstitute for Biological Systems (ISB), CNRLe Bon Samaritain University Hospital ComplexInstitut de Recherche en Elevage Pour Le Développement (IRED) FarchaFaculty of Human Health Sciences, N’Djamena UniversityAbstract Background Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosis. The high rate of asymptomatic infections reflects the reality of SARS-CoV-2 transmission in Chad. In this study, we estimated the seroprevalence and identified factors associated with SARS-CoV-2 infection. Methods A cross-sectional study was conducted between September 2022 and February 2023. A total of 1,290 plasma samples were collected from outpatient attendees at Health Facilities located in 11 provinces of Chad and tested by ELISA method, for the presence of IgG antibodies to SARS-CoV2 nucleocapsid (N) protein. KoboToolbox was used to gather data from the participants and data were analyzed using STATA 16. Results The overall seroprevalence was 83.0% [95% CI = 81.6%—85.5%], with variations between provinces, ranging from 99.2% [95% CI = 94.0%—100%] in Moundou (Southern Chad) to 46.8% [95% CI = 36.0% -57.1%] in Biltine (Eastern Chad). Factors associated with the seroprevalence included military occupation (OR = 0.37 CI [0.80–1.77] p = 0.025) and age group between 55–64 years (OR = 0.33 CI [0.15–0.72] p = 0.005). While, other factors, such as gender and age were not significantly associated with seroprevalence. Conclusion Our results indicated that, the seroprevalence of COVID-19 in Chad is among the highest in Sub-Saharan Africa. These estimates could guide the response and public health policy decisions, enhancing the management of future outbreaks involving respiratory pathogens.https://doi.org/10.1186/s12879-024-10099-4SeroprevalenceSARS-CoV-2COVID-19Associated factorsChad |
| spellingShingle | Koutaya Dezoumbe Oumaima Djarma Andrillene Laure Deutou Wondeu Fatima Abdelrazak Zakaria Sabrina Atturo Nathan Naïbeï Franck J. D. Mennechet Denise Campagna Abdoulaye Boukar Choroma Ahmat Moussa Issa Mahamat Nontegyol Armand Mahamat Idriss Hamad Netalar Honorine Kayanlengar Frederic Adam Adami Moustapha Yanda Mberkissam Daniel Adam Moussa Alim Mahamat Grene Noubaramadji Yamti Suitombaye Amine Akouya Ouchemi Choua Hota Mathieu Djallaye Djimtoïbaye Vittorio Colizzi Giulia Cappelli Takoudjou Dzomo Guy Rodrigue Mahamat Fayiz Abakar Ali Mahamat Moussa SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad BMC Infectious Diseases Seroprevalence SARS-CoV-2 COVID-19 Associated factors Chad |
| title | SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad |
| title_full | SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad |
| title_fullStr | SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad |
| title_full_unstemmed | SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad |
| title_short | SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad |
| title_sort | sars cov 2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in chad |
| topic | Seroprevalence SARS-CoV-2 COVID-19 Associated factors Chad |
| url | https://doi.org/10.1186/s12879-024-10099-4 |
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