Efficient sex hormone biosensors in Saccharomyces cerevisiae cells to evaluate human aromatase activity and inhibition

Efficient sex hormone biosensors in Saccharomyces cerevisiae cells to evaluate human aromatase activity and inhibition

Abstract Yeast sex-hormone whole-cell biosensors are analytical tools characterized by long-time storage and low production cost. We engineered compact β-estradiol biosensors in S. cerevisiae cells by leveraging short (20-nt long) operators bound by the fusion protein LexA-ER-VP64—where ER is the hu...

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Bibliographic Details
Main Authors: Jie Wu, Matthias Bureik, Mario Andrea Marchisio
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Biosensor
CYP enzyme
β-estradiol
Testosterone
Aromatase
Online Access:https://doi.org/10.1038/s41598-024-85022-7
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