A normal genetic variation modulates synaptic MMP‐9 protein levels and the severity of schizophrenia symptoms

A normal genetic variation modulates synaptic MMP‐9 protein levels and the severity of schizophrenia symptoms

Abstract Matrix metalloproteinase 9 (MMP‐9) has recently emerged as a molecule that contributes to pathological synaptic plasticity in schizophrenia, but explanation of the underlying mechanisms has been missing. In the present study, we performed a phenotype‐based genetic association study (PGAS) i...

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Main Authors: Katarzyna Lepeta, Katarzyna J Purzycka, Katarzyna Pachulska‐Wieczorek, Marina Mitjans, Martin Begemann, Behnam Vafadari, Krystian Bijata, Ryszard W Adamiak, Hannelore Ehrenreich, Magdalena Dziembowska, Leszek Kaczmarek
Format: Article
Language:English
Published: Springer Nature 2017-06-01
Series:EMBO Molecular Medicine
Subjects:
dendritic spine morphology
Fragile X mental retardation protein
matrix metalloproteinase 9
phenotype‐based genetic association study
single‐nucleotide polymorphism
Online Access:https://doi.org/10.15252/emmm.201707723
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https://doi.org/10.15252/emmm.201707723

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