FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells

Abstract Genetic lesions drive cancer development and progression, and understanding their origins will reveal the mechanisms of carcinogenesis. We showed that murine FAM72A promotes mutagenic DNA repair during antibody maturation by acting as a substrate adaptor of the CTLHMKLN1 E3 ligase to induce...

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Bibliographic Details
Main Authors: Yuqing Feng, Philip Barbulescu, Chetan K. Chana, Melika Shirdarreh, Hong Yang, Lizhen Wu, Sami Mamand, Mohammad Kashem, Amin Zia, Ming Han, Julissa Tsao, Trevor Pugh, David Cescon, David G. Schatz, Frank Sicheri, Alberto Martin, Rossanna C. Pezo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
FAM72
Cancer
Mutation
Uracil DNA glycosylase 2
Cytosine deamination
Base excision repair
Online Access:https://doi.org/10.1038/s41598-025-07723-x
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