Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients
<b>Background/Objectives:</b> Physicians face clinical dilemmas in the diagnosis of non-optic intraparenchymal lesions on MRI brain scans of patients with neurofibromatosis type 1. As the incidence and evolution of these lesions into adulthood remain unclear, we conducted a retrospective...
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MDPI AG
2024-12-01
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| Series: | Diagnostics |
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| author | Walter Taal Bart Zick Bart J. Emmer Martin J. van den Bent |
| author_facet | Walter Taal Bart Zick Bart J. Emmer Martin J. van den Bent |
| author_sort | Walter Taal |
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| description | <b>Background/Objectives:</b> Physicians face clinical dilemmas in the diagnosis of non-optic intraparenchymal lesions on MRI brain scans of patients with neurofibromatosis type 1. As the incidence and evolution of these lesions into adulthood remain unclear, we conducted a retrospective study on this topic. <b>Methods:</b> All adult neurofibromatosis type 1 patients who had at least one MRI brain scan in our center were selected for this study. Brain lesions with contrast enhancement after gadolinium administration and/or mass effect were named “glioma-like lesions”. <b>Results:</b> In our cohort of 396 adult neurofibromatosis type 1 patients, 182 had at least one MRI scan of the brain. A total of 48 glioma-like lesions were found in 38/182 patients. The majority of glioma-like lesions remained stable, decreased in size or even disappeared during a median follow-up time of 8.5 years. Twelve glioma-like lesions in 11/182 patients were resected or biopsied, and histology showed gliomas of astrocytic origin (WHO grade 1–4). <b>Conclusions:</b> It was concluded from these data that asymptomatic glioma-like lesions on MRI brain scans in neurofibromatosis type 1 patients, either with contrast enhancement and/or mass effect, had an indolent nature. Mildly symptomatic or asymptomatic patients can therefore be followed without invasive diagnostic and therapeutic procedures. |
| format | Article |
| id | doaj-art-fea3534acb3a406b9b3a90914a10b11c |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-fea3534acb3a406b9b3a90914a10b11c2025-01-10T13:16:37ZengMDPI AGDiagnostics2075-44182024-12-011516710.3390/diagnostics15010067Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 PatientsWalter Taal0Bart Zick1Bart J. Emmer2Martin J. van den Bent3Department of Neuro-Oncology/Neurology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The NetherlandsDepartment of Neuro-Oncology/Neurology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology, Erasmus MC, Dr. Molewaterplein 40, 3015 GD Rotterdam, The NetherlandsDepartment of Neuro-Oncology/Neurology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands<b>Background/Objectives:</b> Physicians face clinical dilemmas in the diagnosis of non-optic intraparenchymal lesions on MRI brain scans of patients with neurofibromatosis type 1. As the incidence and evolution of these lesions into adulthood remain unclear, we conducted a retrospective study on this topic. <b>Methods:</b> All adult neurofibromatosis type 1 patients who had at least one MRI brain scan in our center were selected for this study. Brain lesions with contrast enhancement after gadolinium administration and/or mass effect were named “glioma-like lesions”. <b>Results:</b> In our cohort of 396 adult neurofibromatosis type 1 patients, 182 had at least one MRI scan of the brain. A total of 48 glioma-like lesions were found in 38/182 patients. The majority of glioma-like lesions remained stable, decreased in size or even disappeared during a median follow-up time of 8.5 years. Twelve glioma-like lesions in 11/182 patients were resected or biopsied, and histology showed gliomas of astrocytic origin (WHO grade 1–4). <b>Conclusions:</b> It was concluded from these data that asymptomatic glioma-like lesions on MRI brain scans in neurofibromatosis type 1 patients, either with contrast enhancement and/or mass effect, had an indolent nature. Mildly symptomatic or asymptomatic patients can therefore be followed without invasive diagnostic and therapeutic procedures.https://www.mdpi.com/2075-4418/15/1/67neurofibromatosis type 1NF1gliomaadultscohort study |
| spellingShingle | Walter Taal Bart Zick Bart J. Emmer Martin J. van den Bent Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients Diagnostics neurofibromatosis type 1 NF1 glioma adults cohort study |
| title | Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients |
| title_full | Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients |
| title_fullStr | Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients |
| title_full_unstemmed | Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients |
| title_short | Non-Optic Glioma-like Lesions in Adult Neurofibromatosis Type 1 Patients |
| title_sort | non optic glioma like lesions in adult neurofibromatosis type 1 patients |
| topic | neurofibromatosis type 1 NF1 glioma adults cohort study |
| url | https://www.mdpi.com/2075-4418/15/1/67 |
| work_keys_str_mv | AT waltertaal nonopticgliomalikelesionsinadultneurofibromatosistype1patients AT bartzick nonopticgliomalikelesionsinadultneurofibromatosistype1patients AT bartjemmer nonopticgliomalikelesionsinadultneurofibromatosistype1patients AT martinjvandenbent nonopticgliomalikelesionsinadultneurofibromatosistype1patients |