New Pyridinium Compound from Marine Sediment-Derived Bacterium <i>Bacillus licheniformis</i> S-1
The structural diversity of marine natural products is considered a potential resource for the pharmaceutical industry. In our study of marine-derived compounds, one bacterium <i>Bacillus licheniformis</i> S-1 was discovered to have the ability to produce bioactive natural products. Afte...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/1/7 |
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| Summary: | The structural diversity of marine natural products is considered a potential resource for the pharmaceutical industry. In our study of marine-derived compounds, one bacterium <i>Bacillus licheniformis</i> S-1 was discovered to have the ability to produce bioactive natural products. After a further chemistry investigation, one novel 4-aminopyridinium derivative, 4-(dimethylamino)-1-(2<i>S</i>-((4hydroxybenzoyl)oxy)propyl)pyridin-1-ium (<b>1</b>), along with 15 known cyclic dipeptides (<b>2</b>–<b>16</b>) were isolated from the bacterium <i>B. licheniformis</i> S-1 derived from a shallow sea sediment. The structures of compounds <b>1</b>–<b>16</b> were elucidated through comprehensive NMR spectroscopic and specific optical rotation (OR) data analyses. Compound <b>6</b> showed antibacterial activity against <i>Pseudomonas fulva</i> with an MIC value of 50 µg/mL. This is the first study to discover a pyridinium derivative and cyclic dipeptides from <i>B. licheniformis.</i> |
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| ISSN: | 1420-3049 |