Bacillus coagulans-associated severe necrotizing scleral infection
Purpose: We describe a case of severe scleritis possibly caused by Bacillus coagulans. Observations: Conventional laboratory evaluation was inconclusive. The associated organism was identified with metagenomic RNA deep sequencing (MDS). The infection resolved with trimethoprim-sulfamethoxazole treat...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993624001075 |
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| _version_ | 1846117853064855552 |
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| author | Beau Sylvester Spencer D. Fuller Laura Certain Akbar Shakoor Thuy Doan |
| author_facet | Beau Sylvester Spencer D. Fuller Laura Certain Akbar Shakoor Thuy Doan |
| author_sort | Beau Sylvester |
| collection | DOAJ |
| description | Purpose: We describe a case of severe scleritis possibly caused by Bacillus coagulans. Observations: Conventional laboratory evaluation was inconclusive. The associated organism was identified with metagenomic RNA deep sequencing (MDS). The infection resolved with trimethoprim-sulfamethoxazole treatment. Conclusions: This case demonstrates the utility of unbiased, high-throughput sequencing for infectious scleritis. |
| format | Article |
| id | doaj-art-fe6ff6ea330245da8209fdefa2e9071d |
| institution | Kabale University |
| issn | 2451-9936 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj-art-fe6ff6ea330245da8209fdefa2e9071d2024-12-18T08:50:22ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362024-12-0136102097Bacillus coagulans-associated severe necrotizing scleral infectionBeau Sylvester0Spencer D. Fuller1Laura Certain2Akbar Shakoor3Thuy Doan4Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, USADepartment of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, USADepartment of Infectious Diseases, University of Utah School of Medicine, USADepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, USA; Corresponding author. 65 Mario Capecchi Dr., Salt Lake City, UT, 84132, USA.Department of Ophthalmology, University of California San Francisco, San Francisco, USAPurpose: We describe a case of severe scleritis possibly caused by Bacillus coagulans. Observations: Conventional laboratory evaluation was inconclusive. The associated organism was identified with metagenomic RNA deep sequencing (MDS). The infection resolved with trimethoprim-sulfamethoxazole treatment. Conclusions: This case demonstrates the utility of unbiased, high-throughput sequencing for infectious scleritis.http://www.sciencedirect.com/science/article/pii/S2451993624001075Next generation sequencingUveitisSclerokeratitisbacillusFastidious organism |
| spellingShingle | Beau Sylvester Spencer D. Fuller Laura Certain Akbar Shakoor Thuy Doan Bacillus coagulans-associated severe necrotizing scleral infection American Journal of Ophthalmology Case Reports Next generation sequencing Uveitis Sclerokeratitis bacillus Fastidious organism |
| title | Bacillus coagulans-associated severe necrotizing scleral infection |
| title_full | Bacillus coagulans-associated severe necrotizing scleral infection |
| title_fullStr | Bacillus coagulans-associated severe necrotizing scleral infection |
| title_full_unstemmed | Bacillus coagulans-associated severe necrotizing scleral infection |
| title_short | Bacillus coagulans-associated severe necrotizing scleral infection |
| title_sort | bacillus coagulans associated severe necrotizing scleral infection |
| topic | Next generation sequencing Uveitis Sclerokeratitis bacillus Fastidious organism |
| url | http://www.sciencedirect.com/science/article/pii/S2451993624001075 |
| work_keys_str_mv | AT beausylvester bacilluscoagulansassociatedseverenecrotizingscleralinfection AT spencerdfuller bacilluscoagulansassociatedseverenecrotizingscleralinfection AT lauracertain bacilluscoagulansassociatedseverenecrotizingscleralinfection AT akbarshakoor bacilluscoagulansassociatedseverenecrotizingscleralinfection AT thuydoan bacilluscoagulansassociatedseverenecrotizingscleralinfection |