Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel
Cardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better understandin...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-02-01
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| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/8/1/e001592.full |
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| author | Christopher F Spurney Lawrence Charnas Linda Cripe Kan Hor Nicholas King Kathi Kinnett Elizabeth M McNally John-Michael Sauer Lee Sweeney Chet Villa Larry W Markham |
| author_facet | Christopher F Spurney Lawrence Charnas Linda Cripe Kan Hor Nicholas King Kathi Kinnett Elizabeth M McNally John-Michael Sauer Lee Sweeney Chet Villa Larry W Markham |
| author_sort | Christopher F Spurney |
| collection | DOAJ |
| description | Cardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better understanding of the relationship of symptoms, troponin levels and progression of cardiac disease in DMD. As clinical trials begin to assess novel cardiac therapeutics in DMD, troponin levels in DMD are important for safety monitoring and outcome measures. The Parent Project Muscular Dystrophy convened an expert panel of cardiologists, scientists, and regulatory and industry specialists on 16 December 2019 in Silver Spring, Maryland and reviewed published and unpublished data from their institutions. The panel recommended retrospective troponin data analyses, prospective longitudinal troponin collection using high-sensitivity cardiac troponin I assays, inclusion of troponin in future clinical trial outcomes and future development of clinical guidelines for monitoring and treating troponin elevations in DMD. |
| format | Article |
| id | doaj-art-fe6ebdacbf0c47549115ec21cf90fdee |
| institution | Kabale University |
| issn | 2053-3624 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj-art-fe6ebdacbf0c47549115ec21cf90fdee2024-11-12T02:50:09ZengBMJ Publishing GroupOpen Heart2053-36242021-02-018110.1136/openhrt-2021-001592Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panelChristopher F Spurney0Lawrence Charnas1Linda Cripe2Kan Hor3Nicholas King4Kathi Kinnett5Elizabeth M McNally6John-Michael Sauer7Lee Sweeney8Chet Villa9Larry W Markham10Children`s National Heart Institute, Children`s National Hospital, Washington, District of Columbia, USAClinical Research Rare Neurology Disease, Pfizer, Cambridge, Massachusetts, USAThe Heart Center, Nationwide Children`s Hospital, Columbus, Ohio, USAThe Heart Center, Nationwide Children`s Hospital, Columbus, Ohio, USACritical Path Institute, Tucson, Arizona, USAParent Project Muscular Dystrophy, Hackensack, New Jersey, USACenter for Genetic Medicine, Northwestern Medicine, Chicago, Illinois, USACritical Path Institute, Tucson, Arizona, USADepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USACardiology, Cincinnati Children`s Hospital Medical Center, Cincinnati, Ohio, USAPediatrics, Division of Pediatric Cardiology, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, USACardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better understanding of the relationship of symptoms, troponin levels and progression of cardiac disease in DMD. As clinical trials begin to assess novel cardiac therapeutics in DMD, troponin levels in DMD are important for safety monitoring and outcome measures. The Parent Project Muscular Dystrophy convened an expert panel of cardiologists, scientists, and regulatory and industry specialists on 16 December 2019 in Silver Spring, Maryland and reviewed published and unpublished data from their institutions. The panel recommended retrospective troponin data analyses, prospective longitudinal troponin collection using high-sensitivity cardiac troponin I assays, inclusion of troponin in future clinical trial outcomes and future development of clinical guidelines for monitoring and treating troponin elevations in DMD.https://openheart.bmj.com/content/8/1/e001592.full |
| spellingShingle | Christopher F Spurney Lawrence Charnas Linda Cripe Kan Hor Nicholas King Kathi Kinnett Elizabeth M McNally John-Michael Sauer Lee Sweeney Chet Villa Larry W Markham Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel Open Heart |
| title | Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel |
| title_full | Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel |
| title_fullStr | Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel |
| title_full_unstemmed | Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel |
| title_short | Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel |
| title_sort | current state of cardiac troponin testing in duchenne muscular dystrophy cardiomyopathy review and recommendations from the parent project muscular dystrophy expert panel |
| url | https://openheart.bmj.com/content/8/1/e001592.full |
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