Theophylline Revisited. Mechanisms, Challenges, and New Horizons
Introduction and Purpose Theophylline, used for over a century in asthma and COPD treatment, provides anti-inflammatory and bronchodilatory effects via phosphodiesterase inhibition and adenosine receptor antagonism. This review examines its mechanisms, clinical uses, and emerging applications....
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57009 |
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| author | Jakub Szarłowicz Michał Mazur Dorota Waz Zofia Goliszek Karolina Łucja Sobek Wiktoria Tabin-Barczak Aldona Sokołowska Klaudia Fikas Kamil Chwaliszewski Sebastian Samuła |
| author_facet | Jakub Szarłowicz Michał Mazur Dorota Waz Zofia Goliszek Karolina Łucja Sobek Wiktoria Tabin-Barczak Aldona Sokołowska Klaudia Fikas Kamil Chwaliszewski Sebastian Samuła |
| author_sort | Jakub Szarłowicz |
| collection | DOAJ |
| description |
Introduction and Purpose
Theophylline, used for over a century in asthma and COPD treatment, provides anti-inflammatory and bronchodilatory effects via phosphodiesterase inhibition and adenosine receptor antagonism. This review examines its mechanisms, clinical uses, and emerging applications.
Materials and Methods
A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine.
Results
Theophylline shows anti-inflammatory effects, mitochondrial support, and modulation of key pathways (e.g., PI3K/Akt, NF-κB). It demonstrates potential in COVID-19-related ARDS, promoting muscle regeneration, and treating infertility. However, its narrow therapeutic index and variability in pharmacokinetics remain significant challenges.
Conclusion
Theophylline remains a cost-effective option in asthma and COPD and shows promise in broader applications like immunomodulation and metabolic disorders. Further research and advanced drug formulations are needed to enhance its safety and therapeutic potential.
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| format | Article |
| id | doaj-art-fe669e86b9cf4eebbe3c1ba8756cca32 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-fe669e86b9cf4eebbe3c1ba8756cca322025-01-03T08:22:08ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57009Theophylline Revisited. Mechanisms, Challenges, and New HorizonsJakub Szarłowicz0https://orcid.org/0009-0006-8520-9496Michał Mazur1https://orcid.org/0009-0007-3840-4325Dorota Waz2https://orcid.org/0009-0004-7484-9231Zofia Goliszek3https://orcid.org/0009-0005-9881-5754Karolina Łucja Sobek4https://orcid.org/0009-0000-2551-0515Wiktoria Tabin-Barczak5https://orcid.org/0009-0003-8333-8428Aldona Sokołowska6https://orcid.org/0009-0006-8723-2593Klaudia Fikas7https://orcid.org/0009-0008-1976-2941Kamil Chwaliszewski8https://orcid.org/0009-0003-7239-3122Sebastian Samuła9https://orcid.org/0009-0008-8915-4263Medical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandMedical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, PolandMedical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, PolandMedical Center in Łańcut, Poland Ignacego Paderewskiego 5, 37-100 Łańcut, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandProvincial Clinical Hospital No. 2 named after saint Jadwiga the Queen in Rzeszów, Lwowska 60, 35-301 RzeszówUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandStefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ in Lublin, Aleja Kraśnicka 100, 20-718 Lublin, Poland Introduction and Purpose Theophylline, used for over a century in asthma and COPD treatment, provides anti-inflammatory and bronchodilatory effects via phosphodiesterase inhibition and adenosine receptor antagonism. This review examines its mechanisms, clinical uses, and emerging applications. Materials and Methods A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine. Results Theophylline shows anti-inflammatory effects, mitochondrial support, and modulation of key pathways (e.g., PI3K/Akt, NF-κB). It demonstrates potential in COVID-19-related ARDS, promoting muscle regeneration, and treating infertility. However, its narrow therapeutic index and variability in pharmacokinetics remain significant challenges. Conclusion Theophylline remains a cost-effective option in asthma and COPD and shows promise in broader applications like immunomodulation and metabolic disorders. Further research and advanced drug formulations are needed to enhance its safety and therapeutic potential. https://apcz.umk.pl/QS/article/view/57009TheophyllineAsthmaCOPDadenosine antagonistimmunomodulationmitochondria |
| spellingShingle | Jakub Szarłowicz Michał Mazur Dorota Waz Zofia Goliszek Karolina Łucja Sobek Wiktoria Tabin-Barczak Aldona Sokołowska Klaudia Fikas Kamil Chwaliszewski Sebastian Samuła Theophylline Revisited. Mechanisms, Challenges, and New Horizons Quality in Sport Theophylline Asthma COPD adenosine antagonist immunomodulation mitochondria |
| title | Theophylline Revisited. Mechanisms, Challenges, and New Horizons |
| title_full | Theophylline Revisited. Mechanisms, Challenges, and New Horizons |
| title_fullStr | Theophylline Revisited. Mechanisms, Challenges, and New Horizons |
| title_full_unstemmed | Theophylline Revisited. Mechanisms, Challenges, and New Horizons |
| title_short | Theophylline Revisited. Mechanisms, Challenges, and New Horizons |
| title_sort | theophylline revisited mechanisms challenges and new horizons |
| topic | Theophylline Asthma COPD adenosine antagonist immunomodulation mitochondria |
| url | https://apcz.umk.pl/QS/article/view/57009 |
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