Selenium health impacts and Sub-Saharan regional nutritional challenges: Review
Selenium is an important micronutrient that plays key functions in antioxidant defense, immune function, and thyroid health. However, its benefits and risks are closely linked to selenium methylation, a process that significantly influences its biological activity and potential toxicity. This review...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006167 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846128221281583104 |
|---|---|
| author | Loti Kasezga Botha Sydney Namaumbo Noel Jabesi Kapito Patrick Ndovie Deborah Charles Tsukuluza Fatema Jagot Angstone Thembachako Mlangeni |
| author_facet | Loti Kasezga Botha Sydney Namaumbo Noel Jabesi Kapito Patrick Ndovie Deborah Charles Tsukuluza Fatema Jagot Angstone Thembachako Mlangeni |
| author_sort | Loti Kasezga Botha |
| collection | DOAJ |
| description | Selenium is an important micronutrient that plays key functions in antioxidant defense, immune function, and thyroid health. However, its benefits and risks are closely linked to selenium methylation, a process that significantly influences its biological activity and potential toxicity. This review critically analyse the role of selenium methylation in modulating selenium’s effects on health, highlighting its impact on both protective and adverse outcomes. it also discusses the current understanding of selenium’s essential functions and toxicity risks, emphasizing the complexities of Se methylation. The review addresses notable research gaps and controversies, including inconsistent findings on selenium’s cancer-preventive properties, the diverse biological activities of different selenium species, and the challenges in determining optimal selenium intake levels. By synthesizing existing knowledge and identifying key areas for further investigation, this review aims to advance readers’ understanding of selenium’s multifaceted roles that guide future research and public health strategies. |
| format | Article |
| id | doaj-art-fe529fe50f264217a9b946ce2a798031 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-fe529fe50f264217a9b946ce2a7980312024-12-11T05:56:26ZengElsevierResults in Chemistry2211-71562024-12-0112101920Selenium health impacts and Sub-Saharan regional nutritional challenges: ReviewLoti Kasezga Botha0Sydney Namaumbo1Noel Jabesi Kapito2Patrick Ndovie3Deborah Charles Tsukuluza4Fatema Jagot5Angstone Thembachako Mlangeni6Faculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiFaculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiFaculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiFaculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiFaculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiFaculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiCorresponding author.; Faculty of Life Sciences and Natural Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, MalawiSelenium is an important micronutrient that plays key functions in antioxidant defense, immune function, and thyroid health. However, its benefits and risks are closely linked to selenium methylation, a process that significantly influences its biological activity and potential toxicity. This review critically analyse the role of selenium methylation in modulating selenium’s effects on health, highlighting its impact on both protective and adverse outcomes. it also discusses the current understanding of selenium’s essential functions and toxicity risks, emphasizing the complexities of Se methylation. The review addresses notable research gaps and controversies, including inconsistent findings on selenium’s cancer-preventive properties, the diverse biological activities of different selenium species, and the challenges in determining optimal selenium intake levels. By synthesizing existing knowledge and identifying key areas for further investigation, this review aims to advance readers’ understanding of selenium’s multifaceted roles that guide future research and public health strategies.http://www.sciencedirect.com/science/article/pii/S2211715624006167SeleniumImmune functionDietary intakeSelenium deficiencyCancer preventionThyroid health |
| spellingShingle | Loti Kasezga Botha Sydney Namaumbo Noel Jabesi Kapito Patrick Ndovie Deborah Charles Tsukuluza Fatema Jagot Angstone Thembachako Mlangeni Selenium health impacts and Sub-Saharan regional nutritional challenges: Review Results in Chemistry Selenium Immune function Dietary intake Selenium deficiency Cancer prevention Thyroid health |
| title | Selenium health impacts and Sub-Saharan regional nutritional challenges: Review |
| title_full | Selenium health impacts and Sub-Saharan regional nutritional challenges: Review |
| title_fullStr | Selenium health impacts and Sub-Saharan regional nutritional challenges: Review |
| title_full_unstemmed | Selenium health impacts and Sub-Saharan regional nutritional challenges: Review |
| title_short | Selenium health impacts and Sub-Saharan regional nutritional challenges: Review |
| title_sort | selenium health impacts and sub saharan regional nutritional challenges review |
| topic | Selenium Immune function Dietary intake Selenium deficiency Cancer prevention Thyroid health |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006167 |
| work_keys_str_mv | AT lotikasezgabotha seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview AT sydneynamaumbo seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview AT noeljabesikapito seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview AT patrickndovie seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview AT deborahcharlestsukuluza seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview AT fatemajagot seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview AT angstonethembachakomlangeni seleniumhealthimpactsandsubsaharanregionalnutritionalchallengesreview |