Inhibiting astrocyte calcium dynamics terminates status epilepticus via wireless septal stimulation

Inhibiting astrocyte calcium dynamics terminates status epilepticus via wireless septal stimulation

Abstract Status epilepticus (SE) is an acute medical emergency with unclear cellular and circuit mechanisms, and it is imperative to develop anti-SE strategies. Here, we observe distinct astrocytic Ca2+ activity patterns during SE: generalized seizures (GS) show synchronized activity between CA3 and...

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Bibliographic Details
Main Authors: Chunxiao Tian, Qiuying Xue, Tongrui Wu, Jingyu Zhao, Chao Tian, Yuxuan Zhu, Hualin He, Aili Liu, Lei Dong, Yu Zheng, Hui Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Astrocytes
Focal seizure
Generalized seizure
Ca2+ activity
Wireless electrical stimulation
Online Access:https://doi.org/10.1038/s41598-025-09611-w
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