Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells

Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells

Abstract Background Clear cell renal cell carcinoma (ccRCC) is a type of cancer characterized by a vast intracellular accumulation of lipids that are critical to sustain growth and viability of the cells in the tumour microenvironment. Stearoyl-CoA 9-desaturase 1 (SCD-1) is an essential enzyme for t...

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Main Authors: Barbara Guerra, Kristina Jurcic, Rachelle van der Poel, Samantha Lynn Cousineau, Thomas K. Doktor, Laura M. Buchwald, Scott E. Roffey, Caroline A. Lindegaard, Anna Z. Ferrer, Mohammad A. Siddiqui, Laszlo Gyenis, Brage S. Andresen, David W. Litchfield
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
Clear cell renal cell carcinoma
CK2
SCD-1
fatty acids
sunitinib
Online Access:https://doi.org/10.1186/s12935-024-03611-y
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https://doi.org/10.1186/s12935-024-03611-y

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