Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial
BackgroundElectrotherapy has been investigated in chronic pain and diabetic peripheral neuropathy, however prospective trials in patients with chemotherapy-induced peripheral neuropathy (CIPN) are scarce.MethodsFifty-one patients with CIPN ≥ grade 1 subsequent to receiving platinum- and/or taxane-ba...
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Frontiers Media S.A.
2024-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1451456/full |
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| author | Robert Sassmann Simon Peter Gampenrieder Simon Peter Gampenrieder Simon Peter Gampenrieder Florian Rieder Tim Johansson Tim Johansson Gabriel Rinnerthaler Gabriel Rinnerthaler Gabriel Rinnerthaler Gabriel Rinnerthaler Vanessa Castagnaviz Vanessa Castagnaviz Kathrin Lampl Jürgen Herfert Jürgen Herfert Yvonne Theres Kienberger Maria Flamm Dagmar Schaffler-Schaden Richard Greil Richard Greil Richard Greil |
| author_facet | Robert Sassmann Simon Peter Gampenrieder Simon Peter Gampenrieder Simon Peter Gampenrieder Florian Rieder Tim Johansson Tim Johansson Gabriel Rinnerthaler Gabriel Rinnerthaler Gabriel Rinnerthaler Gabriel Rinnerthaler Vanessa Castagnaviz Vanessa Castagnaviz Kathrin Lampl Jürgen Herfert Jürgen Herfert Yvonne Theres Kienberger Maria Flamm Dagmar Schaffler-Schaden Richard Greil Richard Greil Richard Greil |
| author_sort | Robert Sassmann |
| collection | DOAJ |
| description | BackgroundElectrotherapy has been investigated in chronic pain and diabetic peripheral neuropathy, however prospective trials in patients with chemotherapy-induced peripheral neuropathy (CIPN) are scarce.MethodsFifty-one patients with CIPN ≥ grade 1 subsequent to receiving platinum- and/or taxane-based chemotherapy types were randomized to 8 weeks of high tone external muscle stimulation (HTEMS) or transcutaneous electrical nerve stimulation (TENS). The primary outcome were changes in the EORTC-QLQ-CIPN20 questionnaire. Secondary outcomes included clinical examinations, a classification of CIPN according to CTCAE v 4 and the EORTC-QLQ-C30 questionnaire. A control group (n = 17) receiving no intervention was recruited retrospectively.ResultsThe EORTC-QLQ-CIPN20 sensory and motor scales improved in both intervention groups (TENS: −12.3pts and − 8.2pts; HTEMS: −14.7pts and − 8.2pts) with no significant changes in the control group −3.3pts; −2.8pts. The changes in the sensory scale differed significantly between the HTEMS and the control group. In the EORTC-QLQ-C30 questionnaire, there was a significant improvement for physical functioning in the HTEMS group only (+7.9pts) with no between group differences. CIPN classification according to CTCAE v4 improved significantly in both intervention groups.ConclusionHome-based electrotherapy with HTEMS or TENS were successful in improving CIPN-related sensory impairment and could therefore provide a powerful treatment for this side-effect of chemotherapy.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03978585 |
| format | Article |
| id | doaj-art-fe359fa726bb4fb2bee6a8f698202c43 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-fe359fa726bb4fb2bee6a8f698202c432024-12-24T11:39:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.14514561451456Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trialRobert Sassmann0Simon Peter Gampenrieder1Simon Peter Gampenrieder2Simon Peter Gampenrieder3Florian Rieder4Tim Johansson5Tim Johansson6Gabriel Rinnerthaler7Gabriel Rinnerthaler8Gabriel Rinnerthaler9Gabriel Rinnerthaler10Vanessa Castagnaviz11Vanessa Castagnaviz12Kathrin Lampl13Jürgen Herfert14Jürgen Herfert15Yvonne Theres Kienberger16Maria Flamm17Dagmar Schaffler-Schaden18Richard Greil19Richard Greil20Richard Greil21Institute of Physical Medicine and Rehabilitation, Paracelsus Medical University Salzburg, Salzburg, AustriaIIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Salzburg, AustriaSalzburg Cancer Research Institute (SCRI) - Laboratory for Immunological and Molecular Cancer Research (LIMCR) and Center for Clinical Cancer and Immunology Trials (CCCIT), Salzburg, AustriaCancer Cluster Salzburg, Salzburg, AustriaInstitute of Physical Medicine and Rehabilitation, Paracelsus Medical University Salzburg, Salzburg, AustriaInstitute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg, AustriaSalzburg Regional Health Fund (SAGES), Salzburg, AustriaIIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Salzburg, AustriaSalzburg Cancer Research Institute (SCRI) - Laboratory for Immunological and Molecular Cancer Research (LIMCR) and Center for Clinical Cancer and Immunology Trials (CCCIT), Salzburg, AustriaCancer Cluster Salzburg, Salzburg, AustriaDivision of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, Graz, AustriaIIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Salzburg, AustriaSalzburg Cancer Research Institute (SCRI) - Laboratory for Immunological and Molecular Cancer Research (LIMCR) and Center for Clinical Cancer and Immunology Trials (CCCIT), Salzburg, AustriaInstitute of Physical Medicine and Rehabilitation, Paracelsus Medical University Salzburg, Salzburg, AustriaInstitute of Physical Medicine and Rehabilitation, Paracelsus Medical University Salzburg, Salzburg, AustriaRed Bull Athlete Performance Center, Thalgau, AustriaInstitute of Physical Medicine and Rehabilitation, Paracelsus Medical University Salzburg, Salzburg, AustriaInstitute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg, AustriaInstitute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg, AustriaIIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Salzburg, AustriaSalzburg Cancer Research Institute (SCRI) - Laboratory for Immunological and Molecular Cancer Research (LIMCR) and Center for Clinical Cancer and Immunology Trials (CCCIT), Salzburg, AustriaCancer Cluster Salzburg, Salzburg, AustriaBackgroundElectrotherapy has been investigated in chronic pain and diabetic peripheral neuropathy, however prospective trials in patients with chemotherapy-induced peripheral neuropathy (CIPN) are scarce.MethodsFifty-one patients with CIPN ≥ grade 1 subsequent to receiving platinum- and/or taxane-based chemotherapy types were randomized to 8 weeks of high tone external muscle stimulation (HTEMS) or transcutaneous electrical nerve stimulation (TENS). The primary outcome were changes in the EORTC-QLQ-CIPN20 questionnaire. Secondary outcomes included clinical examinations, a classification of CIPN according to CTCAE v 4 and the EORTC-QLQ-C30 questionnaire. A control group (n = 17) receiving no intervention was recruited retrospectively.ResultsThe EORTC-QLQ-CIPN20 sensory and motor scales improved in both intervention groups (TENS: −12.3pts and − 8.2pts; HTEMS: −14.7pts and − 8.2pts) with no significant changes in the control group −3.3pts; −2.8pts. The changes in the sensory scale differed significantly between the HTEMS and the control group. In the EORTC-QLQ-C30 questionnaire, there was a significant improvement for physical functioning in the HTEMS group only (+7.9pts) with no between group differences. CIPN classification according to CTCAE v4 improved significantly in both intervention groups.ConclusionHome-based electrotherapy with HTEMS or TENS were successful in improving CIPN-related sensory impairment and could therefore provide a powerful treatment for this side-effect of chemotherapy.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03978585https://www.frontiersin.org/articles/10.3389/fneur.2024.1451456/fullHTEMSTENShigh tone therapyQLQ-CIPN20QLQ-C30 |
| spellingShingle | Robert Sassmann Simon Peter Gampenrieder Simon Peter Gampenrieder Simon Peter Gampenrieder Florian Rieder Tim Johansson Tim Johansson Gabriel Rinnerthaler Gabriel Rinnerthaler Gabriel Rinnerthaler Gabriel Rinnerthaler Vanessa Castagnaviz Vanessa Castagnaviz Kathrin Lampl Jürgen Herfert Jürgen Herfert Yvonne Theres Kienberger Maria Flamm Dagmar Schaffler-Schaden Richard Greil Richard Greil Richard Greil Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial Frontiers in Neurology HTEMS TENS high tone therapy QLQ-CIPN20 QLQ-C30 |
| title | Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial |
| title_full | Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial |
| title_fullStr | Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial |
| title_full_unstemmed | Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial |
| title_short | Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial |
| title_sort | electrotherapy as treatment for chemotherapy induced peripheral neuropathy a randomized controlled trial |
| topic | HTEMS TENS high tone therapy QLQ-CIPN20 QLQ-C30 |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1451456/full |
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