LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation

LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation

Abstract Background Hepatocellular carcinoma (HCC) is among the deadliest cancers globally. Yes-Associated Protein (YAP), a Hippo pathway effector, crucially regulates cell proliferation and apoptosis. Recent research has implicated YAP’s role in HCC progression, but the mechanisms are unclear. This...

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Bibliographic Details
Main Authors: Xiaoyong Wei, Long Zou, Yanqing Huang, Chuan Qiu, Guang Cheng, Ye Chen, Jun Rao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biology Direct
Subjects:
HCC
YAP
Lactylation
Phosphorylation
Poor prognosis
Online Access:https://doi.org/10.1186/s13062-025-00655-6
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