Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma

Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma

Background CD73–adenosine signaling in the tumor microenvironment is immunosuppressive and may be associated with aggressive renal cell carcinoma (RCC). We investigated the prognostic significance of CD73 protein expression in RCC leveraging nephrectomy samples. We also performed a complementary ana...

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Main Authors: Neeraj Agarwal, Sabina Signoretti, David F McDermott, Toni K Choueiri, Wanling Xie, John A Steinharter, Nieves Martinez-Chanza, Bradley A McGregor, Lauren C Harshman, Abhishek Tripathi, Xiao X Wei, Edwin Lin, Abdallah Flaifel, Emily N Stern Gatof, Gabrielle Bouchard, Justin H Fleischer, Connor Gray, Charlene Mantia, Linda Thompson, Marios Giannakis
Format: Article
Language:English
Published: BMJ Publishing Group 2020-10-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/2/e001467.full
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