Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites
Golden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controve...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250128 |
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| author | Mingzhi Zhu Bohao Shang Fang Zhou Yong Yuan Feiyan Yin Jin Cao Jianan Huang Kunbo Wang Xin Zeng Maiquan Li Zhonghua Liu |
| author_facet | Mingzhi Zhu Bohao Shang Fang Zhou Yong Yuan Feiyan Yin Jin Cao Jianan Huang Kunbo Wang Xin Zeng Maiquan Li Zhonghua Liu |
| author_sort | Mingzhi Zhu |
| collection | DOAJ |
| description | Golden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controversial; the anti-obesity effect of golden-f lower fungus polysaccharides remains unknown. In this study, we identify a golden-f lower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis, which resolves the controversy of classif ication. Moreover, we f ind A. cristatus polysaccharides (ACPS) attenuate obesity in rats. ACPS modulate gut bacterial composition, in which Akkermansia, Akkermansia muciniphila, Bacteroides, Romboutsia, Blautia, and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum, hepatic, and fecal total bile acid content. Furthermore, ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity, according to a fecal transplantation experiment. Thus, ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites. |
| format | Article |
| id | doaj-art-fdf78481a7fc465c9513f7d86d9ab6d0 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-fdf78481a7fc465c9513f7d86d9ab6d02025-01-10T06:54:23ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-05-011331513153010.26599/FSHW.2022.9250128Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolitesMingzhi Zhu0Bohao Shang1Fang Zhou2Yong Yuan3Feiyan Yin4Jin Cao5Jianan Huang6Kunbo Wang7Xin Zeng8Maiquan Li9Zhonghua Liu10College of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaHunan Tea Group Co., Ltd., Changsha 410128, ChinaHunan Tea Group Co., Ltd., Changsha 410128, ChinaHunan Tea Group Co., Ltd., Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Life Sciences, Huaibei Normal University, Huaibei 235000, ChinaSchool of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaGolden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controversial; the anti-obesity effect of golden-f lower fungus polysaccharides remains unknown. In this study, we identify a golden-f lower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis, which resolves the controversy of classif ication. Moreover, we f ind A. cristatus polysaccharides (ACPS) attenuate obesity in rats. ACPS modulate gut bacterial composition, in which Akkermansia, Akkermansia muciniphila, Bacteroides, Romboutsia, Blautia, and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum, hepatic, and fecal total bile acid content. Furthermore, ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity, according to a fecal transplantation experiment. Thus, ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.https://www.sciopen.com/article/10.26599/FSHW.2022.9250128golden-f lower fungusaspergillus cristatuspolysaccharidesobesitygut microbiota |
| spellingShingle | Mingzhi Zhu Bohao Shang Fang Zhou Yong Yuan Feiyan Yin Jin Cao Jianan Huang Kunbo Wang Xin Zeng Maiquan Li Zhonghua Liu Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites Food Science and Human Wellness golden-f lower fungus aspergillus cristatus polysaccharides obesity gut microbiota |
| title | Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites |
| title_full | Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites |
| title_fullStr | Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites |
| title_full_unstemmed | Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites |
| title_short | Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites |
| title_sort | polysaccharides of aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota related metabolites |
| topic | golden-f lower fungus aspergillus cristatus polysaccharides obesity gut microbiota |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250128 |
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