Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

Golden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controve...

Full description

Saved in:
Bibliographic Details
Main Authors: Mingzhi Zhu, Bohao Shang, Fang Zhou, Yong Yuan, Feiyan Yin, Jin Cao, Jianan Huang, Kunbo Wang, Xin Zeng, Maiquan Li, Zhonghua Liu
Format: Article
Language:English
Published: Tsinghua University Press 2024-05-01
Series:Food Science and Human Wellness
Subjects:
golden-f lower fungus
aspergillus cristatus
polysaccharides
obesity
gut microbiota
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2022.9250128
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Golden-flower fungus, the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea, is considered a potential probiotic fungus based on its anti-obesity effect. However, the classif ication of golden-f lower fungi is still controversial; the anti-obesity effect of golden-f lower fungus polysaccharides remains unknown. In this study, we identify a golden-f lower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis, which resolves the controversy of classif ication. Moreover, we f ind A. cristatus polysaccharides (ACPS) attenuate obesity in rats. ACPS modulate gut bacterial composition, in which Akkermansia, Akkermansia muciniphila, Bacteroides, Romboutsia, Blautia, and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum, hepatic, and fecal total bile acid content. Furthermore, ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity, according to a fecal transplantation experiment. Thus, ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.
ISSN:2097-0765
2213-4530

Similar Items