Recent progress in miRNA biogenesis and decay
MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in th...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2023.2288741 |
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| _version_ | 1846128948631568384 |
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| author | Xavier Bofill-De Ros Ulf Andersson Vang Ørom |
| author_facet | Xavier Bofill-De Ros Ulf Andersson Vang Ørom |
| author_sort | Xavier Bofill-De Ros |
| collection | DOAJ |
| description | MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets. |
| format | Article |
| id | doaj-art-fdf211d7639b4afc9d567c6bba940520 |
| institution | Kabale University |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-fdf211d7639b4afc9d567c6bba9405202024-12-10T12:33:41ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-01211364310.1080/15476286.2023.2288741Recent progress in miRNA biogenesis and decayXavier Bofill-De Ros0Ulf Andersson Vang Ørom1RNA Biology and Innovation, Institute of Molecular Biology and Genetics, Aarhus University, Aarhus, DenmarkRNA Biology and Innovation, Institute of Molecular Biology and Genetics, Aarhus University, Aarhus, DenmarkMicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.https://www.tandfonline.com/doi/10.1080/15476286.2023.2288741miRNA biogenesismiRNA decaymiRNA stabilitymiRNA targetingmiRNA therapeutics |
| spellingShingle | Xavier Bofill-De Ros Ulf Andersson Vang Ørom Recent progress in miRNA biogenesis and decay RNA Biology miRNA biogenesis miRNA decay miRNA stability miRNA targeting miRNA therapeutics |
| title | Recent progress in miRNA biogenesis and decay |
| title_full | Recent progress in miRNA biogenesis and decay |
| title_fullStr | Recent progress in miRNA biogenesis and decay |
| title_full_unstemmed | Recent progress in miRNA biogenesis and decay |
| title_short | Recent progress in miRNA biogenesis and decay |
| title_sort | recent progress in mirna biogenesis and decay |
| topic | miRNA biogenesis miRNA decay miRNA stability miRNA targeting miRNA therapeutics |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2023.2288741 |
| work_keys_str_mv | AT xavierbofillderos recentprogressinmirnabiogenesisanddecay AT ulfanderssonvangørom recentprogressinmirnabiogenesisanddecay |