Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma
In the entire world, hepatocellular carcinoma (HCC) is one of the most prevalent cancers. The discovery that HCC is intimately linked to programmed cell death-1 and its ligand (PD-1/PD-L1) in recent years has opened up new possibilities for immunotherapy. However, there are no reliable biomarkers fo...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2023-10-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2310/ObvDqjvIUH3aNnde6f2OXTYE9hQVp1koUOzbPg9z.pdf |
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| author | Hao-Dong QIAO Yi-Fan LIU Ze LIANG Huai-Bin GUO |
| author_facet | Hao-Dong QIAO Yi-Fan LIU Ze LIANG Huai-Bin GUO |
| author_sort | Hao-Dong QIAO |
| collection | DOAJ |
| description | In the entire world, hepatocellular carcinoma (HCC) is one of the most prevalent cancers. The discovery that HCC is intimately linked to programmed cell death-1 and its ligand (PD-1/PD-L1) in recent years has opened up new possibilities for immunotherapy. However, there are no reliable biomarkers for anti-PD-1/PD-L1 immunotherapy. The latest research has found that tertiary lymphoid structures (TLS) have certain predictive value for the anti PD-1/PD-L1 immunotherapy effect of HCC.This paper analyzes the potential of TLS and PD-1/PD-L1 signaling pathway in hepatocellular carcinoma and covers the mechanism of TLS and PD-1/PD-L1 signaling route, their expression in hepatocellular carcinoma, and particular research developments in the clinic. |
| format | Article |
| id | doaj-art-fdee46d5e45f4c96914f9de5550853b6 |
| institution | Kabale University |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2023-10-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-fdee46d5e45f4c96914f9de5550853b62024-12-25T10:11:03ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112023-10-0133537338010.12173/j.issn.1004-5511.2022100036412Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinomaHao-Dong QIAOYi-Fan LIUZe LIANGHuai-Bin GUOIn the entire world, hepatocellular carcinoma (HCC) is one of the most prevalent cancers. The discovery that HCC is intimately linked to programmed cell death-1 and its ligand (PD-1/PD-L1) in recent years has opened up new possibilities for immunotherapy. However, there are no reliable biomarkers for anti-PD-1/PD-L1 immunotherapy. The latest research has found that tertiary lymphoid structures (TLS) have certain predictive value for the anti PD-1/PD-L1 immunotherapy effect of HCC.This paper analyzes the potential of TLS and PD-1/PD-L1 signaling pathway in hepatocellular carcinoma and covers the mechanism of TLS and PD-1/PD-L1 signaling route, their expression in hepatocellular carcinoma, and particular research developments in the clinic.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2310/ObvDqjvIUH3aNnde6f2OXTYE9hQVp1koUOzbPg9z.pdfhepatocellular carcinomaimmunotherapypd-1/pd-l1 signaling pathwaytertiary lymphoid structures |
| spellingShingle | Hao-Dong QIAO Yi-Fan LIU Ze LIANG Huai-Bin GUO Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma Yixue xinzhi zazhi hepatocellular carcinoma immunotherapy pd-1/pd-l1 signaling pathway tertiary lymphoid structures |
| title | Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma |
| title_full | Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma |
| title_fullStr | Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma |
| title_full_unstemmed | Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma |
| title_short | Current perspectives on tertiary lymphoid structures and PD-1/PD-L1 signaling pathway in the immunotherapy of hepatocellular carcinoma |
| title_sort | current perspectives on tertiary lymphoid structures and pd 1 pd l1 signaling pathway in the immunotherapy of hepatocellular carcinoma |
| topic | hepatocellular carcinoma immunotherapy pd-1/pd-l1 signaling pathway tertiary lymphoid structures |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2310/ObvDqjvIUH3aNnde6f2OXTYE9hQVp1koUOzbPg9z.pdf |
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