The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats
This study aims to determine the effect of chronic administration of amphetamine-type stimulants at varying doses on inflammation and oxidative stress in Wistar rats. They were given methylphenidate and divided into 4 treatment groups. Furthermore, simple random grouping was carried out to divide t...
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University of Baghdad, College of Science for Women
2024-07-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9170 |
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| author | Vita Camellia Fasihah Irfani Fitri Muhammad Ichwan Dina Keumala Sari Elmeida Effendy Aldy Safruddin Rambe Syafruddin Ilyas Juliandi Alfi Khatib Mustafa Mahmud Amin Muhammad Rusda |
| author_facet | Vita Camellia Fasihah Irfani Fitri Muhammad Ichwan Dina Keumala Sari Elmeida Effendy Aldy Safruddin Rambe Syafruddin Ilyas Juliandi Alfi Khatib Mustafa Mahmud Amin Muhammad Rusda |
| author_sort | Vita Camellia |
| collection | DOAJ |
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This study aims to determine the effect of chronic administration of amphetamine-type stimulants at varying doses on inflammation and oxidative stress in Wistar rats. They were given methylphenidate and divided into 4 treatment groups. Furthermore, simple random grouping was carried out to divide the samples into 5 groups, each consisting of 9 rats. These groups included rats given only distilled water as the controls, as well as those given methylphenidate at doses of 10 mg/kg BW, 20 mg/kg BW, and 40 mg/kg BW for 4 weeks as the experimental groups. Statistical analysis was then performed using GraphPad Prism to compare the effects of oxidative stress, systemic inflammation, BDNF, and spatial memory of the Wistar rats. Chronic administration of stimulants led to a significant decrease in glutathione peroxidase levels as well as an increase in the release of IL-6 and tumor necrosis factor-α compared to the control group. Based on the results, the pathways involved in cognitive impairment, which were related to the use of amphetamine-type stimulants played a role in addressing the detrimental effect of substance abuse and their comorbidities
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| format | Article |
| id | doaj-art-fddc0bcd494c4caaa89948cc191d29bc |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-fddc0bcd494c4caaa89948cc191d29bc2025-08-20T03:58:03ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-07-0121710.21123/bsj.2023.9170The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar RatsVita Camellia0https://orcid.org/0000-0001-5774-3276Fasihah Irfani Fitri1https://orcid.org/0000-0002-0883-3029Muhammad Ichwan2https://orcid.org/0000-0001-8380-9099Dina Keumala Sari3Elmeida Effendy4Aldy Safruddin Rambe5Syafruddin Ilyas6Juliandi7https://orcid.org/0000-0002-1090-2003Alfi Khatib8Mustafa Mahmud Amin9Muhammad Rusda10https://orcid.org/0000-0002-2268-6838Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia & Department of Psychiatry, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Department of Neurology, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Department of Nutrition, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Department of Psychiatry, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Department of Neurology, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Faculty of Biology, Universitas Sumatra Utara, Medan, Indonesia.Department of Public Health, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Faculty of Pharmacy, International Islamic University Malaysia, Kuala Lumpur, Malaysia.Department of Psychiatry, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia.Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia. This study aims to determine the effect of chronic administration of amphetamine-type stimulants at varying doses on inflammation and oxidative stress in Wistar rats. They were given methylphenidate and divided into 4 treatment groups. Furthermore, simple random grouping was carried out to divide the samples into 5 groups, each consisting of 9 rats. These groups included rats given only distilled water as the controls, as well as those given methylphenidate at doses of 10 mg/kg BW, 20 mg/kg BW, and 40 mg/kg BW for 4 weeks as the experimental groups. Statistical analysis was then performed using GraphPad Prism to compare the effects of oxidative stress, systemic inflammation, BDNF, and spatial memory of the Wistar rats. Chronic administration of stimulants led to a significant decrease in glutathione peroxidase levels as well as an increase in the release of IL-6 and tumor necrosis factor-α compared to the control group. Based on the results, the pathways involved in cognitive impairment, which were related to the use of amphetamine-type stimulants played a role in addressing the detrimental effect of substance abuse and their comorbidities https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9170amphetamine-type stimulants, glutathione peroxidase, IL-6, inflammation, oxidative stress, tumor necrosis factor-α |
| spellingShingle | Vita Camellia Fasihah Irfani Fitri Muhammad Ichwan Dina Keumala Sari Elmeida Effendy Aldy Safruddin Rambe Syafruddin Ilyas Juliandi Alfi Khatib Mustafa Mahmud Amin Muhammad Rusda The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats مجلة بغداد للعلوم amphetamine-type stimulants, glutathione peroxidase, IL-6, inflammation, oxidative stress, tumor necrosis factor-α |
| title | The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats |
| title_full | The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats |
| title_fullStr | The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats |
| title_full_unstemmed | The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats |
| title_short | The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats |
| title_sort | effect of chronic administration of amphetamine type stimulants on oxidative stress and inflammation in wistar rats |
| topic | amphetamine-type stimulants, glutathione peroxidase, IL-6, inflammation, oxidative stress, tumor necrosis factor-α |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9170 |
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