Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus
Vibrio alginolyticus, an emergent species of Vibrio genus, exists in aquatic and marine environments. It has undergone genetic diversification, but its detailed genomic diversity is still unclear. Here, we performed a multi-dimensional comparative genomic analysis to explore the population phylogeny...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2350164 |
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| author | Zhenzhou Huang Yanjun Li Keyi Yu Lizhi Ma Bo Pang Qin Qin Jie Li Duochun Wang He Gao Biao Kan |
| author_facet | Zhenzhou Huang Yanjun Li Keyi Yu Lizhi Ma Bo Pang Qin Qin Jie Li Duochun Wang He Gao Biao Kan |
| author_sort | Zhenzhou Huang |
| collection | DOAJ |
| description | Vibrio alginolyticus, an emergent species of Vibrio genus, exists in aquatic and marine environments. It has undergone genetic diversification, but its detailed genomic diversity is still unclear. Here, we performed a multi-dimensional comparative genomic analysis to explore the population phylogeny, virulence-related genes and potential drug resistance genes of 184 V. alginolyticus isolates. Although genetic diversity is complex, we analysed the population structure using three sub-datasets, including the subdivision for three lineages into sublineages and the distribution of strains in the marine ecological niche. Accessory genes, most of which reclassified V. alginolyticus genomes as different but with relatively close affinities, were nonuniformly distributed among these isolates. We demonstrated that the spread of some post-evolutionary isolates (mainly L3 strains isolated from Chinese territorial seas) was likely to be closely related to human activities, whereas other more ancestral strains (strains in the L1 and L2) tended to be locally endemic and formed clonal complex groups. In terms of pathogenicity, the potential virulence factors were mainly associated with toxin, adherence, motility, chemotaxis, and the type III secretion system (T3SS). We also found five types of antibacterial drug resistance genes. The prevalence of β-lactam resistance genes was 100%, which indicated that there may be a potential risk of natural resistance to β-lactam drugs. Our study reveals insights into genomic characteristics, evolution and potential virulence-associated gene profiles of V. alginolyticus. |
| format | Article |
| id | doaj-art-fdc8b45de1cf40f5b70ea9d60f81fe5f |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-fdc8b45de1cf40f5b70ea9d60f81fe5f2024-12-07T04:40:17ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2350164Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticusZhenzhou Huang0Yanjun Li1Keyi Yu2Lizhi Ma3Bo Pang4Qin Qin5Jie Li6Duochun Wang7He Gao8Biao Kan9National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaThe Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaThe Third Medical Center, Chinese PLA (People’s Liberation Army) General Hospital, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaVibrio alginolyticus, an emergent species of Vibrio genus, exists in aquatic and marine environments. It has undergone genetic diversification, but its detailed genomic diversity is still unclear. Here, we performed a multi-dimensional comparative genomic analysis to explore the population phylogeny, virulence-related genes and potential drug resistance genes of 184 V. alginolyticus isolates. Although genetic diversity is complex, we analysed the population structure using three sub-datasets, including the subdivision for three lineages into sublineages and the distribution of strains in the marine ecological niche. Accessory genes, most of which reclassified V. alginolyticus genomes as different but with relatively close affinities, were nonuniformly distributed among these isolates. We demonstrated that the spread of some post-evolutionary isolates (mainly L3 strains isolated from Chinese territorial seas) was likely to be closely related to human activities, whereas other more ancestral strains (strains in the L1 and L2) tended to be locally endemic and formed clonal complex groups. In terms of pathogenicity, the potential virulence factors were mainly associated with toxin, adherence, motility, chemotaxis, and the type III secretion system (T3SS). We also found five types of antibacterial drug resistance genes. The prevalence of β-lactam resistance genes was 100%, which indicated that there may be a potential risk of natural resistance to β-lactam drugs. Our study reveals insights into genomic characteristics, evolution and potential virulence-associated gene profiles of V. alginolyticus.https://www.tandfonline.com/doi/10.1080/22221751.2024.2350164Vibrio alginolyticuswhole genome sequencingpopulation structurevirulence-related factorsantibiotic resistance genes |
| spellingShingle | Zhenzhou Huang Yanjun Li Keyi Yu Lizhi Ma Bo Pang Qin Qin Jie Li Duochun Wang He Gao Biao Kan Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus Emerging Microbes and Infections Vibrio alginolyticus whole genome sequencing population structure virulence-related factors antibiotic resistance genes |
| title | Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus |
| title_full | Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus |
| title_fullStr | Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus |
| title_full_unstemmed | Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus |
| title_short | Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus |
| title_sort | genome wide expanding of genetic evolution and potential pathogenicity in vibrio alginolyticus |
| topic | Vibrio alginolyticus whole genome sequencing population structure virulence-related factors antibiotic resistance genes |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2350164 |
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