Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway

Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway

Abstract The aim of this study was to investigate the key targets and signaling pathways of paeoniflorin (PF) for the treatment of gastric cancer (GC). First, the differentially expressed genes (DEGs) of gastric cancer were obtained by analyzing GSE118916 Gene Chip, and then the active components of...

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Bibliographic Details
Main Authors: Yating Yang, Ling Yuan, Yuhua Du, Mengyi Ye, Doudou Lu, Shicong Huang, Jianjun Zhao, Joanna Japhet Tibenda, Fandi Meng, Yi Nan
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Discover Oncology
Subjects:
Paeoniflorin
Gastric cancer
RAS/MAPK
Network pharmacology
Bioinformatics
Online Access:https://doi.org/10.1007/s12672-024-01532-w
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