ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release
We present a new application of positron emission tomography (“ntPET” or “neurotransmitter PET”) designed to recover temporal patterns of neurotransmitter release from dynamic data. Our approach employs an enhanced tracer kinetic model that describes uptake of a labeled dopamine D2/D3 receptor ligan...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2005-10-01
|
| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2005.05130 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841564626395856896 |
|---|---|
| author | Evan D. Morris Karmen K. Yoder Chunzhi Wang Marc D. Normandin Qi-Huang Zheng Bruce Mock F. Muzic Raymond Janice C. Froehlich |
| author_facet | Evan D. Morris Karmen K. Yoder Chunzhi Wang Marc D. Normandin Qi-Huang Zheng Bruce Mock F. Muzic Raymond Janice C. Froehlich |
| author_sort | Evan D. Morris |
| collection | DOAJ |
| description | We present a new application of positron emission tomography (“ntPET” or “neurotransmitter PET”) designed to recover temporal patterns of neurotransmitter release from dynamic data. Our approach employs an enhanced tracer kinetic model that describes uptake of a labeled dopamine D2/D3 receptor ligand in the presence of a time-varying rise and fall in endogenous dopamine. Data must be acquired during both baseline and stimulus (transient dopamine release) conditions. Data from a reference region in both conditions are used as an input function, which alleviates the need for any arterial blood sampling. We use simulation studies to demonstrate the ability of the method to recover the temporal characteristics of an increase in dopamine concentration that might be expected following a drug treatment. The accuracy and precision of the method—as well as its potential for false-positive responses due to noise or changes in blood flow—were examined. Finally, we applied the ntPET method to small-animal imaging data in order to produce the first noninvasive assay of the time-varying release of dopamine in the rat striatum following alcohol. |
| format | Article |
| id | doaj-art-fd8448691cd540ca9efeef390d19d51f |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2005-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-fd8448691cd540ca9efeef390d19d51f2025-01-02T22:37:55ZengSAGE PublishingMolecular Imaging1536-01212005-10-01410.2310/7290.2005.0513010.2310_7290.2005.05130ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter ReleaseEvan D. Morris0Karmen K. Yoder1Chunzhi Wang2Marc D. Normandin3Qi-Huang Zheng4Bruce Mock5F. Muzic Raymond6Janice C. Froehlich7Purdue University, West Lafayette, INIndiana University School of Medicine, Indianapolis, INIndiana University School of Medicine, Indianapolis, INPurdue University, West Lafayette, INIndiana University School of Medicine, Indianapolis, INIndiana University School of Medicine, Indianapolis, INCase Western Reserve University, Cleveland, OHIndiana University School of Medicine, Indianapolis, INWe present a new application of positron emission tomography (“ntPET” or “neurotransmitter PET”) designed to recover temporal patterns of neurotransmitter release from dynamic data. Our approach employs an enhanced tracer kinetic model that describes uptake of a labeled dopamine D2/D3 receptor ligand in the presence of a time-varying rise and fall in endogenous dopamine. Data must be acquired during both baseline and stimulus (transient dopamine release) conditions. Data from a reference region in both conditions are used as an input function, which alleviates the need for any arterial blood sampling. We use simulation studies to demonstrate the ability of the method to recover the temporal characteristics of an increase in dopamine concentration that might be expected following a drug treatment. The accuracy and precision of the method—as well as its potential for false-positive responses due to noise or changes in blood flow—were examined. Finally, we applied the ntPET method to small-animal imaging data in order to produce the first noninvasive assay of the time-varying release of dopamine in the rat striatum following alcohol.https://doi.org/10.2310/7290.2005.05130 |
| spellingShingle | Evan D. Morris Karmen K. Yoder Chunzhi Wang Marc D. Normandin Qi-Huang Zheng Bruce Mock F. Muzic Raymond Janice C. Froehlich ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release Molecular Imaging |
| title | ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release |
| title_full | ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release |
| title_fullStr | ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release |
| title_full_unstemmed | ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release |
| title_short | ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release |
| title_sort | ntpet a new application of pet imaging for characterizing the kinetics of endogenous neurotransmitter release |
| url | https://doi.org/10.2310/7290.2005.05130 |
| work_keys_str_mv | AT evandmorris ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT karmenkyoder ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT chunzhiwang ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT marcdnormandin ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT qihuangzheng ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT brucemock ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT fmuzicraymond ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease AT janicecfroehlich ntpetanewapplicationofpetimagingforcharacterizingthekineticsofendogenousneurotransmitterrelease |