Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer
Breast cancer is the most common cancer diagnosed in women and is often treated with chemotherapy. Although previous studies have demonstrated increasing biological age in patients who receive chemotherapy, evaluation of this association with DNA methylation-based markers of biological ageing may pr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2024.2360160 |
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| author | Drew R. Nannini Rene Cortese Christopher VonTungeln Gerhard C. Hildebrandt |
| author_facet | Drew R. Nannini Rene Cortese Christopher VonTungeln Gerhard C. Hildebrandt |
| author_sort | Drew R. Nannini |
| collection | DOAJ |
| description | Breast cancer is the most common cancer diagnosed in women and is often treated with chemotherapy. Although previous studies have demonstrated increasing biological age in patients who receive chemotherapy, evaluation of this association with DNA methylation-based markers of biological ageing may provide novel insight into the role of chemotherapy on the ageing process. We therefore sought to investigate the association between chemotherapy and markers of biological ageing as estimated from DNA methylation in women with breast cancer. DNA methylation profiling was performed on peripheral blood collected from 18 patients before and after the first cycle of chemotherapy using the Infinium HumanMethylation450 BeadChip. Six markers of biological age acceleration were estimated from DNA methylation levels. Multiple linear regression analyses were performed to evaluate the association between each metric of biological age acceleration and chemotherapy. After adjusting for chronological age and race, intrinsic epigenetic age acceleration (p = 0.041), extrinsic epigenetic age acceleration (p = 0.050), PhenoAge acceleration (p = 0.001), GrimAge acceleration (p < 0.001), and DunedinPACE (p = 0.006) were significantly higher and telomere length (p = 0.027) was significantly lower following the first cycle of chemotherapy compared to before treatment initiation. These results demonstrate greater biological ageing as estimated from DNA methylation following chemotherapy in women with breast cancer. Our findings illustrate that cytotoxic therapies may modulate the ageing process among breast cancer patients and may also have implications for age-related health conditions in cancer survivors. |
| format | Article |
| id | doaj-art-fd373f908b7e44d4b961837eafa15364 |
| institution | Kabale University |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-fd373f908b7e44d4b961837eafa153642024-12-09T07:21:36ZengTaylor & Francis GroupEpigenetics1559-22941559-23082024-12-0119110.1080/15592294.2024.2360160Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancerDrew R. Nannini0Rene Cortese1Christopher VonTungeln2Gerhard C. Hildebrandt3Department of Internal Medicine, School of Medicine, University of Missouri at Columbia, Columbia, MO, USADepartment of Child Health and Department of Obstetrics, Gynecology, and Women’s Health, School of Medicine, University of Missouri at Columbia, Columbia, MO, USADepartment of Internal Medicine, School of Medicine, University of Missouri at Columbia, Columbia, MO, USAEllis Fischel Cancer Center, University of Missouri at Columbia, Columbia, MO, USABreast cancer is the most common cancer diagnosed in women and is often treated with chemotherapy. Although previous studies have demonstrated increasing biological age in patients who receive chemotherapy, evaluation of this association with DNA methylation-based markers of biological ageing may provide novel insight into the role of chemotherapy on the ageing process. We therefore sought to investigate the association between chemotherapy and markers of biological ageing as estimated from DNA methylation in women with breast cancer. DNA methylation profiling was performed on peripheral blood collected from 18 patients before and after the first cycle of chemotherapy using the Infinium HumanMethylation450 BeadChip. Six markers of biological age acceleration were estimated from DNA methylation levels. Multiple linear regression analyses were performed to evaluate the association between each metric of biological age acceleration and chemotherapy. After adjusting for chronological age and race, intrinsic epigenetic age acceleration (p = 0.041), extrinsic epigenetic age acceleration (p = 0.050), PhenoAge acceleration (p = 0.001), GrimAge acceleration (p < 0.001), and DunedinPACE (p = 0.006) were significantly higher and telomere length (p = 0.027) was significantly lower following the first cycle of chemotherapy compared to before treatment initiation. These results demonstrate greater biological ageing as estimated from DNA methylation following chemotherapy in women with breast cancer. Our findings illustrate that cytotoxic therapies may modulate the ageing process among breast cancer patients and may also have implications for age-related health conditions in cancer survivors.https://www.tandfonline.com/doi/10.1080/15592294.2024.2360160breast cancerchemotherapyepigenetic agebiological ageing |
| spellingShingle | Drew R. Nannini Rene Cortese Christopher VonTungeln Gerhard C. Hildebrandt Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer Epigenetics breast cancer chemotherapy epigenetic age biological ageing |
| title | Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer |
| title_full | Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer |
| title_fullStr | Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer |
| title_full_unstemmed | Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer |
| title_short | Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer |
| title_sort | chemotherapy induced acceleration of dna methylation based biological age in breast cancer |
| topic | breast cancer chemotherapy epigenetic age biological ageing |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2024.2360160 |
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