Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis
Abstract Objective Sarcopenia, a condition characterized by the gradual decline of muscle mass, strength, and function, is a key indicator of malnutrition in cancer patients and has been linked to poor prognoses in oncology. Sarcopenia is commonly assessed by measuring the skeletal muscle index (SMI...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-025-13430-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544558313209856 |
|---|---|
| author | Na Aru Congyu Yang Yuntian Chen Jiaming Liu |
| author_facet | Na Aru Congyu Yang Yuntian Chen Jiaming Liu |
| author_sort | Na Aru |
| collection | DOAJ |
| description | Abstract Objective Sarcopenia, a condition characterized by the gradual decline of muscle mass, strength, and function, is a key indicator of malnutrition in cancer patients and has been linked to poor prognoses in oncology. Sarcopenia is commonly assessed by measuring the skeletal muscle index (SMI) of the third lumbar spine (L3) using computed tomography (CT). This meta-analysis aimed to explore the relationship between low SMI and clinicopathological features, as well as prognosis, in individuals with endometrial cancer (EC). Methods Data from various databases including PubMed, Embase, Cochrane, Medline, and Web of Science were searched up until October 20th, 2024. Studies that investigated the association of low SMI and EC survival or clinicopathological characteristics were included. Pooled effect sizes were reported as hazards ratio (HR), odds ratios (ORs) or weighted mean difference (WMD). The quality and risk of bias in the studies were evaluated using the Newcastle-Ottawa Scale (NOS) and the Quality In Prognosis Studies (QUIPS), and the study was registered on PROSPERO (CRD42024509949) before commencing the search. Results A total of 218 studies were identified across all five databases, with 11 studies meeting the criteria for qualitative and quantitative analysis, involving 1588 patients. The findings of our meta-analysis demonstrated a significant link between low SMI and progression-free survival [P = 0.002; HR: 1.62, 95% CI: 1.20–2.17]. Low SMI was also associated with a BMI < 25 (P < 0.00001; OR: 4.55, 95% CI: 3.01–6.87), FIGO stage (P = 0.04; OR: 1.33, 95% CI: 1.01–1.75), pathology grades (P = 0.001; OR: 1.77, 95% CI: 1.26–2.49), and the endometrioid pathological type (P = 0.01; OR: 0.68, 95% CI: 0.51–0.92). However, no significant correlation was found between low SMI and 5-year overall survival, serous pathological type, recurrence, length of hospital stay, intraoperative complications, and postoperative complications. All the included studies scored ≥ 7 on the NOS, indicating relatively high-quality evidence. Conclusions The meta-analysis highlighted the association between low SMI and unfavorable clinical features and outcomes in EC patients, emphasizing the importance of early diagnosis and appropriate management of sarcopenia assessed by low SMI to enhance prognoses in EC patients. |
| format | Article |
| id | doaj-art-fd13f11a46ad478ba222c73d80947f4f |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-fd13f11a46ad478ba222c73d80947f4f2025-01-12T12:27:22ZengBMCBMC Cancer1471-24072025-01-0125111110.1186/s12885-025-13430-7Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysisNa Aru0Congyu Yang1Yuntian Chen2Jiaming Liu3Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Urology, West China Hospital, Sichuan UniversityAbstract Objective Sarcopenia, a condition characterized by the gradual decline of muscle mass, strength, and function, is a key indicator of malnutrition in cancer patients and has been linked to poor prognoses in oncology. Sarcopenia is commonly assessed by measuring the skeletal muscle index (SMI) of the third lumbar spine (L3) using computed tomography (CT). This meta-analysis aimed to explore the relationship between low SMI and clinicopathological features, as well as prognosis, in individuals with endometrial cancer (EC). Methods Data from various databases including PubMed, Embase, Cochrane, Medline, and Web of Science were searched up until October 20th, 2024. Studies that investigated the association of low SMI and EC survival or clinicopathological characteristics were included. Pooled effect sizes were reported as hazards ratio (HR), odds ratios (ORs) or weighted mean difference (WMD). The quality and risk of bias in the studies were evaluated using the Newcastle-Ottawa Scale (NOS) and the Quality In Prognosis Studies (QUIPS), and the study was registered on PROSPERO (CRD42024509949) before commencing the search. Results A total of 218 studies were identified across all five databases, with 11 studies meeting the criteria for qualitative and quantitative analysis, involving 1588 patients. The findings of our meta-analysis demonstrated a significant link between low SMI and progression-free survival [P = 0.002; HR: 1.62, 95% CI: 1.20–2.17]. Low SMI was also associated with a BMI < 25 (P < 0.00001; OR: 4.55, 95% CI: 3.01–6.87), FIGO stage (P = 0.04; OR: 1.33, 95% CI: 1.01–1.75), pathology grades (P = 0.001; OR: 1.77, 95% CI: 1.26–2.49), and the endometrioid pathological type (P = 0.01; OR: 0.68, 95% CI: 0.51–0.92). However, no significant correlation was found between low SMI and 5-year overall survival, serous pathological type, recurrence, length of hospital stay, intraoperative complications, and postoperative complications. All the included studies scored ≥ 7 on the NOS, indicating relatively high-quality evidence. Conclusions The meta-analysis highlighted the association between low SMI and unfavorable clinical features and outcomes in EC patients, emphasizing the importance of early diagnosis and appropriate management of sarcopenia assessed by low SMI to enhance prognoses in EC patients.https://doi.org/10.1186/s12885-025-13430-7Skeletal muscle indexSarcopeniaEndometrial cancerClinical characteristicPrognosisMeta-analysis |
| spellingShingle | Na Aru Congyu Yang Yuntian Chen Jiaming Liu Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis BMC Cancer Skeletal muscle index Sarcopenia Endometrial cancer Clinical characteristic Prognosis Meta-analysis |
| title | Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis |
| title_full | Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis |
| title_fullStr | Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis |
| title_full_unstemmed | Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis |
| title_short | Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis |
| title_sort | low l3 skeletal muscle index and endometrial cancer a statistic pooling analysis |
| topic | Skeletal muscle index Sarcopenia Endometrial cancer Clinical characteristic Prognosis Meta-analysis |
| url | https://doi.org/10.1186/s12885-025-13430-7 |
| work_keys_str_mv | AT naaru lowl3skeletalmuscleindexandendometrialcancerastatisticpoolinganalysis AT congyuyang lowl3skeletalmuscleindexandendometrialcancerastatisticpoolinganalysis AT yuntianchen lowl3skeletalmuscleindexandendometrialcancerastatisticpoolinganalysis AT jiamingliu lowl3skeletalmuscleindexandendometrialcancerastatisticpoolinganalysis |