Radiochemistry for positron emission tomography
Abstract Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET imaging has been used to diagnose and monitor the progression of diseases, as well as to facilitate drug development efforts at both preclinical and cli...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36377-4 |
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| _version_ | 1841544558088814592 |
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| author | Jian Rong Achi Haider Troels E. Jeppesen Lee Josephson Steven H. Liang |
| author_facet | Jian Rong Achi Haider Troels E. Jeppesen Lee Josephson Steven H. Liang |
| author_sort | Jian Rong |
| collection | DOAJ |
| description | Abstract Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET imaging has been used to diagnose and monitor the progression of diseases, as well as to facilitate drug development efforts at both preclinical and clinical stages. The wide applications and rapid development of PET have ultimately led to an increasing demand for new methods in radiochemistry, with the aim to expand the scope of synthons amenable for radiolabeling. In this work, we provide an overview of commonly used chemical transformations for the syntheses of PET tracers in all aspects of radiochemistry, thereby highlighting recent breakthrough discoveries and contemporary challenges in the field. We discuss the use of biologicals for PET imaging and highlight general examples of successful probe discoveries for molecular imaging with PET – with a particular focus on translational and scalable radiochemistry concepts that have been entered to clinical use. |
| format | Article |
| id | doaj-art-fd0ebc3222f8447caabbefd5963ae7f7 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-fd0ebc3222f8447caabbefd5963ae7f72025-01-12T12:29:26ZengNature PortfolioNature Communications2041-17232023-06-0114112310.1038/s41467-023-36377-4Radiochemistry for positron emission tomographyJian Rong0Achi Haider1Troels E. Jeppesen2Lee Josephson3Steven H. Liang4Department of Radiology and Imaging Sciences, Emory UniversityDepartment of Radiology and Imaging Sciences, Emory UniversityDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical SchoolDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical SchoolDepartment of Radiology and Imaging Sciences, Emory UniversityAbstract Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET imaging has been used to diagnose and monitor the progression of diseases, as well as to facilitate drug development efforts at both preclinical and clinical stages. The wide applications and rapid development of PET have ultimately led to an increasing demand for new methods in radiochemistry, with the aim to expand the scope of synthons amenable for radiolabeling. In this work, we provide an overview of commonly used chemical transformations for the syntheses of PET tracers in all aspects of radiochemistry, thereby highlighting recent breakthrough discoveries and contemporary challenges in the field. We discuss the use of biologicals for PET imaging and highlight general examples of successful probe discoveries for molecular imaging with PET – with a particular focus on translational and scalable radiochemistry concepts that have been entered to clinical use.https://doi.org/10.1038/s41467-023-36377-4 |
| spellingShingle | Jian Rong Achi Haider Troels E. Jeppesen Lee Josephson Steven H. Liang Radiochemistry for positron emission tomography Nature Communications |
| title | Radiochemistry for positron emission tomography |
| title_full | Radiochemistry for positron emission tomography |
| title_fullStr | Radiochemistry for positron emission tomography |
| title_full_unstemmed | Radiochemistry for positron emission tomography |
| title_short | Radiochemistry for positron emission tomography |
| title_sort | radiochemistry for positron emission tomography |
| url | https://doi.org/10.1038/s41467-023-36377-4 |
| work_keys_str_mv | AT jianrong radiochemistryforpositronemissiontomography AT achihaider radiochemistryforpositronemissiontomography AT troelsejeppesen radiochemistryforpositronemissiontomography AT leejosephson radiochemistryforpositronemissiontomography AT stevenhliang radiochemistryforpositronemissiontomography |