Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life

Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life

Abstract Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer’s disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2–7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain...

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Main Authors: James M. Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Håkon Grydeland, Esten H. Leonardsen, Olena Iakunchykova, Mengyu Pan, Athanasia Mowinckel, Marie Strømstad, Laura Nawijn, Yuri Milaneschi, Micael Andersson, Sara Pudas, Anne Cecilie Sjøli Bråthen, Jonas Kransberg, Emilie Sogn Falch, Knut Øverbye, Rogier A. Kievit, Klaus P. Ebmeier, Ulman Lindenberger, Paolo Ghisletta, Naiara Demnitz, Carl-Johan Boraxbekk, Christian A. Drevon, Alzheimer’s Disease Neuroimaging Initiative, the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing, Brenda Penninx, Lars Bertram, Lars Nyberg, Kristine B. Walhovd, Anders M. Fjell, Yunpeng Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53548-z
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