Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration

Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration

Background The proliferative capacity of cardiomyocytes in adult mammalian hearts is far too low to replace the cells that are lost to myocardial infarction. Both cardiomyocyte proliferation and myocardial regeneration can be improved via the overexpression of a constitutively active variant of YAP5...

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Bibliographic Details
Main Authors: Yongyu Wang, Yalin Wu, Yu Jiang, Huilan Tan, Bijay Guragain, Thanh Nguyen, Jianli Zhao, Yang Zhou, Yuji Nakada, Jianyi Zhang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyocyte
modified RNA
myocardial infarction
YAP5SA
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.037120
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