An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement
The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contras...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2005-01-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1162/15353500200504181 |
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| author | Cynthia Ménard Robert C. Susil Peter Choyke Jonathan Coleman Robert Grubb Ahmed Gharib Axel Krieger Peter Guion David Thomasson Karen Ullman Sandeep Gupta Virginia Espina Lance Liotta Emanuel Petricoin Gabor Fitchtinger Louis L. Whitcomb Ergin Atalar C. Norman Coleman Kevin Camphausen |
| author_facet | Cynthia Ménard Robert C. Susil Peter Choyke Jonathan Coleman Robert Grubb Ahmed Gharib Axel Krieger Peter Guion David Thomasson Karen Ullman Sandeep Gupta Virginia Espina Lance Liotta Emanuel Petricoin Gabor Fitchtinger Louis L. Whitcomb Ergin Atalar C. Norman Coleman Kevin Camphausen |
| author_sort | Cynthia Ménard |
| collection | DOAJ |
| description | The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer. |
| format | Article |
| id | doaj-art-fcc0f23f5f8040dca07bd3cf844626f2 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-fcc0f23f5f8040dca07bd3cf844626f22025-01-02T22:38:07ZengSAGE PublishingMolecular Imaging1536-01212005-01-01410.1162/1535350020050418110.1162_15353500200504181An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast EnhancementCynthia Ménard0Robert C. Susil1Peter Choyke2Jonathan Coleman3Robert Grubb4Ahmed Gharib5Axel Krieger6Peter Guion7David Thomasson8Karen Ullman9Sandeep Gupta10Virginia Espina11Lance Liotta12Emanuel Petricoin13Gabor Fitchtinger14Louis L. Whitcomb15Ergin Atalar16C. Norman Coleman17Kevin Camphausen18University of TorontoJohns Hopkins UniversityNIH/DHHSNIH/DHHSNIH/DHHSNIH/DHHSJohns Hopkins UniversityNIH/DHHSNIH/DHHSNIH/DHHSGE Healthcare TechnologiesNIH/DHHSNIH/DHHSFood and Drug AdministrationJohns Hopkins UniversityJohns Hopkins UniversityJohns Hopkins UniversityNIH/DHHSNIH/DHHSThe biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer.https://doi.org/10.1162/15353500200504181 |
| spellingShingle | Cynthia Ménard Robert C. Susil Peter Choyke Jonathan Coleman Robert Grubb Ahmed Gharib Axel Krieger Peter Guion David Thomasson Karen Ullman Sandeep Gupta Virginia Espina Lance Liotta Emanuel Petricoin Gabor Fitchtinger Louis L. Whitcomb Ergin Atalar C. Norman Coleman Kevin Camphausen An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement Molecular Imaging |
| title | An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement |
| title_full | An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement |
| title_fullStr | An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement |
| title_full_unstemmed | An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement |
| title_short | An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement |
| title_sort | interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement |
| url | https://doi.org/10.1162/15353500200504181 |
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