Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase
Evidence is growing that the cAMP pathway through the cAMP responsive element binding protein (CREB) transcription factor plays an important role in long-term memory formation (LTM). To study the role of ß-noradrenergic receptors, positively linked to the cAMP secondmessenger system, in the dynamics...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.1998.63 |
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| author | Pascal Roullet Susan Sara |
| author_facet | Pascal Roullet Susan Sara |
| author_sort | Pascal Roullet |
| collection | DOAJ |
| description | Evidence is growing that the cAMP pathway through the cAMP responsive element binding protein (CREB) transcription factor plays an important role in long-term memory formation (LTM). To study the role of ß-noradrenergic receptors, positively linked to the cAMP secondmessenger system, in the dynamics of LTM processes, we used a memory-reactivation paradigm because recent studies in our laboratory confirmed that reactivated memory is labile and undergoes an extended reconsolidation process. In an eight-arm maze, rats were trained to choose the same three baited arms; 24 hr later, memory was reactivated and then the rats were injected intracerebroventricularly at 5 min, 30 min, 60 min, or 5 hr later with the ß-antagonist timolol or with saline. The results showed that injection of timolol induced amnesia only at the 60 min post-reactivation interval, whereas all control groups and groups that were timolol-injected at other post-reactivation intervals displayed optimal retention. The delayed amnesic action of timoloi suggests that ß noradrenergic receptors and the cAMP cascade are implicated in the late phase of reprocessing of a remembered event. |
| format | Article |
| id | doaj-art-fcafc7e35d604bdcbd840d1dbee84bdc |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-fcafc7e35d604bdcbd840d1dbee84bdc2025-02-03T05:53:19ZengWileyNeural Plasticity2090-59041687-54431998-01-0163636810.1155/NP.1998.63Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late PhasePascal Roullet0Susan Sara1Neuromodulation et Processus Cognitifs, lnstitut des Neurosciences, CNRS UMR 7624, Université Pierre et Marie Curie, 9 quai St-Bernard, Paris 75005, FranceNeuromodulation et Processus Cognitifs, lnstitut des Neurosciences, CNRS UMR 7624, Université Pierre et Marie Curie, 9 quai St-Bernard, Paris 75005, FranceEvidence is growing that the cAMP pathway through the cAMP responsive element binding protein (CREB) transcription factor plays an important role in long-term memory formation (LTM). To study the role of ß-noradrenergic receptors, positively linked to the cAMP secondmessenger system, in the dynamics of LTM processes, we used a memory-reactivation paradigm because recent studies in our laboratory confirmed that reactivated memory is labile and undergoes an extended reconsolidation process. In an eight-arm maze, rats were trained to choose the same three baited arms; 24 hr later, memory was reactivated and then the rats were injected intracerebroventricularly at 5 min, 30 min, 60 min, or 5 hr later with the ß-antagonist timolol or with saline. The results showed that injection of timolol induced amnesia only at the 60 min post-reactivation interval, whereas all control groups and groups that were timolol-injected at other post-reactivation intervals displayed optimal retention. The delayed amnesic action of timoloi suggests that ß noradrenergic receptors and the cAMP cascade are implicated in the late phase of reprocessing of a remembered event.http://dx.doi.org/10.1155/NP.1998.63 |
| spellingShingle | Pascal Roullet Susan Sara Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase Neural Plasticity |
| title | Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase |
| title_full | Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase |
| title_fullStr | Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase |
| title_full_unstemmed | Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase |
| title_short | Consolidation of Memory After its Reactivation: Involvement of ß Noradrenergic Receptors in the Late Phase |
| title_sort | consolidation of memory after its reactivation involvement of ss noradrenergic receptors in the late phase |
| url | http://dx.doi.org/10.1155/NP.1998.63 |
| work_keys_str_mv | AT pascalroullet consolidationofmemoryafteritsreactivationinvolvementofßnoradrenergicreceptorsinthelatephase AT susansara consolidationofmemoryafteritsreactivationinvolvementofßnoradrenergicreceptorsinthelatephase |