RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

Ferroptosis is a distinct iron-dependent programmed cell death and plays important roles in tumor suppression. However, the regulatory mechanisms of ferroptosis need further exploration. RUNT-related transcription factor 2 (RUNX2), a transcription factor, is essential for osteogenesis. RUNX2 has two...

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Bibliographic Details
Main Authors: Junjun Huang, Rong Jia, Jihua Guo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
RUNX2 isoform II
PRDX2
ferroptosis
apoptosis
oral squamous cell carcinoma
Online Access:https://elifesciences.org/articles/99122
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