Review: trends in nanotherapeutics to manage Helicobacter pylori
Antibiotics have been extensively used in the eradication of Helicobacter pylori, but their effectiveness is hindered by the bacterium’s ability to acquire resistance. Further, the drug’s short residence time and low bioavailability in the gastric environment (low pH, presence of digestive enzymes,...
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| Format: | Article |
| Language: | English |
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Verduci Editore
2024-09-01
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| Series: | Microbiota in Health and Disease |
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| Online Access: | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/09/e1038.pdf |
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| _version_ | 1841560934097616896 |
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| author | R. Chitas P. Parreira M.C. Martins |
| author_facet | R. Chitas P. Parreira M.C. Martins |
| author_sort | R. Chitas |
| collection | DOAJ |
| description | Antibiotics have been extensively used in the eradication of Helicobacter pylori, but their effectiveness is hindered by the bacterium’s ability to acquire resistance. Further, the drug’s short residence time and low bioavailability in the gastric environment (low pH, presence of digestive enzymes, and difficulty in crossing the mucus layer) also challenge the treatment. Nanotherapeutics to protect and increase antimicrobials residence time in gastric settings and new bactericidal strategies based on localized formation of reactive oxygen species (ROS), after intrinsic (acidic pH) or extrinsic (light source or ultrasound device) stimulus have been developed for gastric infection management. Here the most promising nanotherapeutics published from June 2023 to June 2024, retrieved on PubMed and Scopus using the search keywords “Nanotherapeutics”, “Nanoparticles”, “Bioengineered”, “Biomaterials”, plus “Helicobacter pylori”, are briefly highlighted. |
| format | Article |
| id | doaj-art-fca22c01ae73426a9362fb9af0d4a851 |
| institution | Kabale University |
| issn | 2704-8845 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Microbiota in Health and Disease |
| spelling | doaj-art-fca22c01ae73426a9362fb9af0d4a8512025-01-03T10:30:12ZengVerduci EditoreMicrobiota in Health and Disease2704-88452024-09-01610.26355/mhd_20249_10381038Review: trends in nanotherapeutics to manage Helicobacter pyloriR. Chitas0P. Parreira1M.C. Martins2i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugali3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugali3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, PortugalAntibiotics have been extensively used in the eradication of Helicobacter pylori, but their effectiveness is hindered by the bacterium’s ability to acquire resistance. Further, the drug’s short residence time and low bioavailability in the gastric environment (low pH, presence of digestive enzymes, and difficulty in crossing the mucus layer) also challenge the treatment. Nanotherapeutics to protect and increase antimicrobials residence time in gastric settings and new bactericidal strategies based on localized formation of reactive oxygen species (ROS), after intrinsic (acidic pH) or extrinsic (light source or ultrasound device) stimulus have been developed for gastric infection management. Here the most promising nanotherapeutics published from June 2023 to June 2024, retrieved on PubMed and Scopus using the search keywords “Nanotherapeutics”, “Nanoparticles”, “Bioengineered”, “Biomaterials”, plus “Helicobacter pylori”, are briefly highlighted.https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/09/e1038.pdfhelicobacter pyloribioengineeringnanoparticlesnanotherapeuticssonodynamic therapyphotodynamic therapy. |
| spellingShingle | R. Chitas P. Parreira M.C. Martins Review: trends in nanotherapeutics to manage Helicobacter pylori Microbiota in Health and Disease helicobacter pylori bioengineering nanoparticles nanotherapeutics sonodynamic therapy photodynamic therapy. |
| title | Review: trends in nanotherapeutics to manage Helicobacter pylori |
| title_full | Review: trends in nanotherapeutics to manage Helicobacter pylori |
| title_fullStr | Review: trends in nanotherapeutics to manage Helicobacter pylori |
| title_full_unstemmed | Review: trends in nanotherapeutics to manage Helicobacter pylori |
| title_short | Review: trends in nanotherapeutics to manage Helicobacter pylori |
| title_sort | review trends in nanotherapeutics to manage helicobacter pylori |
| topic | helicobacter pylori bioengineering nanoparticles nanotherapeutics sonodynamic therapy photodynamic therapy. |
| url | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/09/e1038.pdf |
| work_keys_str_mv | AT rchitas reviewtrendsinnanotherapeuticstomanagehelicobacterpylori AT pparreira reviewtrendsinnanotherapeuticstomanagehelicobacterpylori AT mcmartins reviewtrendsinnanotherapeuticstomanagehelicobacterpylori |