Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury
Reported changes in electroencephalography (EEG)-derived spectral power after mild traumatic brain injury (mTBI) remains inconsistent across existing literature. However, this may be a result of previous analyses depending solely on observing spectral power within traditional canonical frequency ban...
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Mary Ann Liebert
2024-11-01
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| Series: | Neurotrauma Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/neur.2024.0004 |
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| author | Mark C. Nwakamma Alexandra M. Stillman Laurel J. Gabard-Durnam James F. Cavanagh Charles H. Hillman Timothy P. Morris |
| author_facet | Mark C. Nwakamma Alexandra M. Stillman Laurel J. Gabard-Durnam James F. Cavanagh Charles H. Hillman Timothy P. Morris |
| author_sort | Mark C. Nwakamma |
| collection | DOAJ |
| description | Reported changes in electroencephalography (EEG)-derived spectral power after mild traumatic brain injury (mTBI) remains inconsistent across existing literature. However, this may be a result of previous analyses depending solely on observing spectral power within traditional canonical frequency bands rather than accounting for the aperiodic activity within the collected neural signal. Therefore, the aim of this study was to test for differences in rhythmic and arrhythmic time series across the brain, and in the cognitively relevant frontoparietal (FP) network, and observe whether those differences were associated with cognitive recovery post-mTBI. Resting-state electroencephalography (rs-EEG) was collected from 88 participants (56 mTBI and 32 age- and sex-matched healthy controls) within 14 days of injury for the mTBI participants. A battery of executive function (EF) tests was collected at the first session with follow-up metrics collected approximately 2 and 4 months after the initial visit. After spectral parameterization, a significant between-group difference in aperiodic-adjusted alpha center peak frequency within the FP network was observed, where a slowing of alpha peak frequency was found in the mTBI group in comparison to the healthy controls. This slowing of week 2 (collected within 2 weeks of injury) aperiodic-adjusted alpha center peak frequency within the FP network was associated with increased EF over time (evaluated using executive composite scores) post-mTBI. These findings suggest alpha center peak frequency within the FP network as a candidate prognostic marker of EF recovery and may inform clinical rehabilitative methods post-mTBI. |
| format | Article |
| id | doaj-art-fc8e09d24a3148cc879bd1ebcd3fb53d |
| institution | Kabale University |
| issn | 2689-288X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj-art-fc8e09d24a3148cc879bd1ebcd3fb53d2025-08-20T03:49:37ZengMary Ann LiebertNeurotrauma Reports2689-288X2024-11-015144846110.1089/neur.2024.0004Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain InjuryMark C. Nwakamma0Alexandra M. Stillman1Laurel J. Gabard-Durnam2James F. Cavanagh3Charles H. Hillman4Timothy P. Morris5Department of Physical Therapy Human Movement Sciences, Northeastern University, Boston, Massachusetts, USA.Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.Department of Psychology, Northeastern University, Boston, Massachusetts, USA.Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.Department of Physical Therapy Human Movement Sciences, Northeastern University, Boston, Massachusetts, USA.Department of Physical Therapy Human Movement Sciences, Northeastern University, Boston, Massachusetts, USA.Reported changes in electroencephalography (EEG)-derived spectral power after mild traumatic brain injury (mTBI) remains inconsistent across existing literature. However, this may be a result of previous analyses depending solely on observing spectral power within traditional canonical frequency bands rather than accounting for the aperiodic activity within the collected neural signal. Therefore, the aim of this study was to test for differences in rhythmic and arrhythmic time series across the brain, and in the cognitively relevant frontoparietal (FP) network, and observe whether those differences were associated with cognitive recovery post-mTBI. Resting-state electroencephalography (rs-EEG) was collected from 88 participants (56 mTBI and 32 age- and sex-matched healthy controls) within 14 days of injury for the mTBI participants. A battery of executive function (EF) tests was collected at the first session with follow-up metrics collected approximately 2 and 4 months after the initial visit. After spectral parameterization, a significant between-group difference in aperiodic-adjusted alpha center peak frequency within the FP network was observed, where a slowing of alpha peak frequency was found in the mTBI group in comparison to the healthy controls. This slowing of week 2 (collected within 2 weeks of injury) aperiodic-adjusted alpha center peak frequency within the FP network was associated with increased EF over time (evaluated using executive composite scores) post-mTBI. These findings suggest alpha center peak frequency within the FP network as a candidate prognostic marker of EF recovery and may inform clinical rehabilitative methods post-mTBI.https://www.liebertpub.com/doi/10.1089/neur.2024.0004alpha peak frequencyaperiodic activityEEGmTBIspectral parameterization |
| spellingShingle | Mark C. Nwakamma Alexandra M. Stillman Laurel J. Gabard-Durnam James F. Cavanagh Charles H. Hillman Timothy P. Morris Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury Neurotrauma Reports alpha peak frequency aperiodic activity EEG mTBI spectral parameterization |
| title | Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury |
| title_full | Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury |
| title_fullStr | Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury |
| title_full_unstemmed | Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury |
| title_short | Slowing of Parameterized Resting-State Electroencephalography After Mild Traumatic Brain Injury |
| title_sort | slowing of parameterized resting state electroencephalography after mild traumatic brain injury |
| topic | alpha peak frequency aperiodic activity EEG mTBI spectral parameterization |
| url | https://www.liebertpub.com/doi/10.1089/neur.2024.0004 |
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