Extraction-free RT-RPA assay for detection of HPV16, HPV18, and HPV45 mRNA expression

Extraction-free RT-RPA assay for detection of HPV16, HPV18, and HPV45 mRNA expression

Abstract Messenger RNA (mRNA) from high-risk genotypes of human papillomavirus (hrHPV) is a more specific biomarker for cervical cancer risk than hrHPV DNA due to its ability to differentiate clinically significant infections from transient ones. Detecting mRNA from exfoliated cervical cells, howeve...

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Main Authors: Emilie Newsham Novak, Ariel Ma, Kathryn A. Kundrod, Megan M. Chang, Cannon J. Hansen, Jane Richards Montealegre, Michael E. Scheurer, Philip E. Castle, Ming Guo, Mila P. Salcedo, Kathleen Schmeler, Rebecca Richards-Kortum
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-13583-2
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https://doi.org/10.1038/s41598-025-13583-2

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