Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control
Abstract Malaria is a significant public health challenge in Gabon, with high prevalence rates in rural and semi-urban areas. This study investigated Plasmodium infection prevalence among outpatients at a medical laboratory in Franceville, Gabon, in 2020. Data from 500 patients were analyzed, reveal...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83487-0 |
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| author | Larson Boundenga Yann Vital Sima-Biyang Neil Michel Longo-Pendy Michelle Bignoumba Clark Mbou-Boutambe Clauve Jauvert Moukagni-Mussadji Dorothé Marielle Wora Fabrice Kassa-Kassa Richard Onanga Cyrille Bisseye Francine Ntoumi Ayola Akim Adegnika Jean-Bernard Lekana-Douki |
| author_facet | Larson Boundenga Yann Vital Sima-Biyang Neil Michel Longo-Pendy Michelle Bignoumba Clark Mbou-Boutambe Clauve Jauvert Moukagni-Mussadji Dorothé Marielle Wora Fabrice Kassa-Kassa Richard Onanga Cyrille Bisseye Francine Ntoumi Ayola Akim Adegnika Jean-Bernard Lekana-Douki |
| author_sort | Larson Boundenga |
| collection | DOAJ |
| description | Abstract Malaria is a significant public health challenge in Gabon, with high prevalence rates in rural and semi-urban areas. This study investigated Plasmodium infection prevalence among outpatients at a medical laboratory in Franceville, Gabon, in 2020. Data from 500 patients were analyzed, revealing an overall infection rate of 33.2% and the presence of four Plasmodium species: P. falciparum, P. malariae, P. ovale, and possibly P. vivax for the first time in Gabon. Co-infections were common, with P. falciparum and P. ovale spp. being the most prevalent at 23.5%. Asymptomatic infections accounted for 81.3% of cases, while symptomatic infections were 18.7%. P. falciparum was associated with symptomatic cases, while non-falciparum species were linked to asymptomatic infections. The findings suggest Franceville has perennial malaria transmission, highlighting the role of Plasmodium species diversity in disease severity and clinical presentation, including the first report of P. vivax infection in the Gabonese population. |
| format | Article |
| id | doaj-art-fc7b4981cb1f4d278734a2acfdf6dfe7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-fc7b4981cb1f4d278734a2acfdf6dfe72025-01-05T12:25:23ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-83487-0Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria controlLarson Boundenga0Yann Vital Sima-Biyang1Neil Michel Longo-Pendy2Michelle Bignoumba3Clark Mbou-Boutambe4Clauve Jauvert Moukagni-Mussadji5Dorothé Marielle Wora6Fabrice Kassa-Kassa7Richard Onanga8Cyrille Bisseye9Francine Ntoumi10Ayola Akim Adegnika11Jean-Bernard Lekana-Douki12Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Interdisciplinary Centre of Medical Research of Franceville (CIRMF)Cellular Biology (LABMC), Masuku University of Science and TechnologyFondation Congolaise pour la Recherche Medicale (FCRM)Institute of Tropical Medicine, University of TübingenInterdisciplinary Centre of Medical Research of Franceville (CIRMF)Abstract Malaria is a significant public health challenge in Gabon, with high prevalence rates in rural and semi-urban areas. This study investigated Plasmodium infection prevalence among outpatients at a medical laboratory in Franceville, Gabon, in 2020. Data from 500 patients were analyzed, revealing an overall infection rate of 33.2% and the presence of four Plasmodium species: P. falciparum, P. malariae, P. ovale, and possibly P. vivax for the first time in Gabon. Co-infections were common, with P. falciparum and P. ovale spp. being the most prevalent at 23.5%. Asymptomatic infections accounted for 81.3% of cases, while symptomatic infections were 18.7%. P. falciparum was associated with symptomatic cases, while non-falciparum species were linked to asymptomatic infections. The findings suggest Franceville has perennial malaria transmission, highlighting the role of Plasmodium species diversity in disease severity and clinical presentation, including the first report of P. vivax infection in the Gabonese population.https://doi.org/10.1038/s41598-024-83487-0MalariaDiagnosisPlasmodium speciesFrancevilleGabon |
| spellingShingle | Larson Boundenga Yann Vital Sima-Biyang Neil Michel Longo-Pendy Michelle Bignoumba Clark Mbou-Boutambe Clauve Jauvert Moukagni-Mussadji Dorothé Marielle Wora Fabrice Kassa-Kassa Richard Onanga Cyrille Bisseye Francine Ntoumi Ayola Akim Adegnika Jean-Bernard Lekana-Douki Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control Scientific Reports Malaria Diagnosis Plasmodium species Franceville Gabon |
| title | Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control |
| title_full | Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control |
| title_fullStr | Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control |
| title_full_unstemmed | Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control |
| title_short | Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control |
| title_sort | epidemiology and diversity of plasmodium species in franceville and their implications for malaria control |
| topic | Malaria Diagnosis Plasmodium species Franceville Gabon |
| url | https://doi.org/10.1038/s41598-024-83487-0 |
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