Green Synthesis of Trifluoromethanesulfonyl Fluoride as an Eco-Friendly Alternative to SF<sub>6</sub> Gas Insulation and Analysis of Its Acute Inhalation Toxicity

Green Synthesis of Trifluoromethanesulfonyl Fluoride as an Eco-Friendly Alternative to SF<sub>6</sub> Gas Insulation and Analysis of Its Acute Inhalation Toxicity

This study demonstrates an eco-friendly synthesis of trifluoromethanesulfonyl fluoride (TFSF) as a sustainable SF<sub>6</sub> alternative. Optimized halogen exchange reactions using CF<sub>3</sub>SO<sub>2</sub>Cl/KF (3:1 ratio) with crown ether catalysis at low te...

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Bibliographic Details
Main Authors: Shile Wang, Li Dong, Ruichao Peng, Hongding Tang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
TFSF
green synthesis
halogen exchange
acute inhalation toxicity
SF<sub>6</sub> alternative
Online Access:https://www.mdpi.com/1420-3049/30/10/2241
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Summary:This study demonstrates an eco-friendly synthesis of trifluoromethanesulfonyl fluoride (TFSF) as a sustainable SF<sub>6</sub> alternative. Optimized halogen exchange reactions using CF<sub>3</sub>SO<sub>2</sub>Cl/KF (3:1 ratio) with crown ether catalysis at low temperatures achieved 65% TFSF yield (97.9% purity). Scale-up trials in pressurized reactors showed >50% conversion and >90% selectivity. Acute inhalation tests (OECD standards) on Sprague-Dawley rats revealed transient toxicity at 20,000 ppm (4 h exposure), with survival rates >66% and LC<sub>50</sub> exceeding 22,600 ppm—significantly safer than SF<sub>6</sub>. These findings confirm TFSF’s technical viability and low toxicity, positioning it as a practical insulating medium to curb SF<sub>6</sub> emissions. The methodology highlights precision halogen exchange control and systematic safety validation, offering actionable solutions for industrial adoption.
ISSN:1420-3049

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