Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
Background. Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran. Methods. The thin-layer ch...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2021/9968730 |
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| _version_ | 1841524676071784448 |
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| author | Farzin Firozian Amir Nili-Ahmadabadi Shirin Moradkhani Miad Moulaei Zohreh Fasihi Davoud Ahmadimoghaddam |
| author_facet | Farzin Firozian Amir Nili-Ahmadabadi Shirin Moradkhani Miad Moulaei Zohreh Fasihi Davoud Ahmadimoghaddam |
| author_sort | Farzin Firozian |
| collection | DOAJ |
| description | Background. Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran. Methods. The thin-layer chromatography method was applied for the primary screening of potential illicit substances in the samples. The positive samples were analyzed using an isocratic high-performance liquid chromatography method. Results. The results showed that 26.98% of the samples contained 17.76 ± 6.02 mg/cap of sibutramine. Daily therapeutic dose intake of sibutramine is in the range of 5 to 15 mg daily. Conclusion. Since apothecaries have advised consumers to take at least two capsules a day, it seems that the blood concentration of sibutramine will likely rise beyond the therapeutic concentration and become toxic. Therefore, the usage of such products could pose serious risks to consumers’ health. |
| format | Article |
| id | doaj-art-fc23f816816d4270ab27126fd9cfa8dd |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-fc23f816816d4270ab27126fd9cfa8dd2025-02-03T05:47:39ZengWileyJournal of Obesity2090-07082090-07162021-01-01202110.1155/2021/99687309968730Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot StudyFarzin Firozian0Amir Nili-Ahmadabadi1Shirin Moradkhani2Miad Moulaei3Zohreh Fasihi4Davoud Ahmadimoghaddam5Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranFood and Drug Control Laboratory, Hamadan University of Medical Sciences, Hamadan, IranMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranBackground. Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran. Methods. The thin-layer chromatography method was applied for the primary screening of potential illicit substances in the samples. The positive samples were analyzed using an isocratic high-performance liquid chromatography method. Results. The results showed that 26.98% of the samples contained 17.76 ± 6.02 mg/cap of sibutramine. Daily therapeutic dose intake of sibutramine is in the range of 5 to 15 mg daily. Conclusion. Since apothecaries have advised consumers to take at least two capsules a day, it seems that the blood concentration of sibutramine will likely rise beyond the therapeutic concentration and become toxic. Therefore, the usage of such products could pose serious risks to consumers’ health.http://dx.doi.org/10.1155/2021/9968730 |
| spellingShingle | Farzin Firozian Amir Nili-Ahmadabadi Shirin Moradkhani Miad Moulaei Zohreh Fasihi Davoud Ahmadimoghaddam Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study Journal of Obesity |
| title | Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study |
| title_full | Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study |
| title_fullStr | Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study |
| title_full_unstemmed | Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study |
| title_short | Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study |
| title_sort | adulteration of the herbal weight loss products by the illegal addition of synthetic antiobesity medications a pilot study |
| url | http://dx.doi.org/10.1155/2021/9968730 |
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