Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment
Abstract. Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions. However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. Distinguishin...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2024-12-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003450 |
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| author | Tianning Huang Fan Li Yiming Wang Jian Gu Ling Lu Peifang Wei |
| author_facet | Tianning Huang Fan Li Yiming Wang Jian Gu Ling Lu Peifang Wei |
| author_sort | Tianning Huang |
| collection | DOAJ |
| description | Abstract. Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions. However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. Distinguishing specific TI-Treg subpopulations from peripheral Tregs and intratumoral conventional T cells (Tconvs) has recently emerged as an important topic in antitumor therapy. In this review, we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies. Although the phenotypic and functional diversity of TI-Tregs remains unclear, our review provides new insights into TI-Treg-based therapies and facilitates precision medicine for tumor treatment. |
| format | Article |
| id | doaj-art-fc21ec3eacdf4b1cac5b947eed28915c |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-fc21ec3eacdf4b1cac5b947eed28915c2025-01-10T01:10:24ZengWolters KluwerChinese Medical Journal0366-69992542-56412024-12-01137242996300910.1097/CM9.0000000000003450202412200-00005Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironmentTianning Huang0Fan Li1Yiming Wang2Jian Gu3Ling Lu4Peifang Wei1 Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China1 Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China1 Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China1 Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China1 Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, ChinaAbstract. Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions. However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. Distinguishing specific TI-Treg subpopulations from peripheral Tregs and intratumoral conventional T cells (Tconvs) has recently emerged as an important topic in antitumor therapy. In this review, we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies. Although the phenotypic and functional diversity of TI-Tregs remains unclear, our review provides new insights into TI-Treg-based therapies and facilitates precision medicine for tumor treatment.http://journals.lww.com/10.1097/CM9.0000000000003450 |
| spellingShingle | Tianning Huang Fan Li Yiming Wang Jian Gu Ling Lu Peifang Wei Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment Chinese Medical Journal |
| title | Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment |
| title_full | Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment |
| title_fullStr | Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment |
| title_full_unstemmed | Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment |
| title_short | Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment |
| title_sort | tumor infiltrating regulatory t cell a promising therapeutic target in tumor microenvironment |
| url | http://journals.lww.com/10.1097/CM9.0000000000003450 |
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