Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not
Abstract Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Viruses |
| Online Access: | https://doi.org/10.1038/s44298-024-00068-8 |
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| author | Kiyoko Iwatsuki-Horimoto Maki Kiso Mutsumi Ito Seiya Yamayoshi Yoshihiro Kawaoka |
| author_facet | Kiyoko Iwatsuki-Horimoto Maki Kiso Mutsumi Ito Seiya Yamayoshi Yoshihiro Kawaoka |
| author_sort | Kiyoko Iwatsuki-Horimoto |
| collection | DOAJ |
| description | Abstract Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibility to SARS-CoV-2 varies. Knowledge of virus transmissibility from humans to pet rodents is important for public health to assess the potential for transmission in the home and pet breeding and selling facilities. In this study, we assessed the sensitivity of guinea pigs and gerbils to SARS-CoV-2 isolated from humans, and found that gerbils are susceptible to SARS-CoV-2, but guinea pigs are not. Pet sellers often display hamsters with high susceptibility to SARS-CoV-2 in the same area as gerbils, so caution should be exercised during COVID-19 outbreaks. |
| format | Article |
| id | doaj-art-fc0535727ff147f4b99bfb662bb4ad00 |
| institution | Kabale University |
| issn | 2948-1767 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Viruses |
| spelling | doaj-art-fc0535727ff147f4b99bfb662bb4ad002024-11-24T12:14:11ZengNature Portfolionpj Viruses2948-17672024-11-01211610.1038/s44298-024-00068-8Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are notKiyoko Iwatsuki-Horimoto0Maki Kiso1Mutsumi Ito2Seiya Yamayoshi3Yoshihiro Kawaoka4Division of Virology, Institute of Medical Science, University of TokyoDivision of Virology, Institute of Medical Science, University of TokyoDivision of Virology, Institute of Medical Science, University of TokyoDivision of Virology, Institute of Medical Science, University of TokyoDivision of Virology, Institute of Medical Science, University of TokyoAbstract Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibility to SARS-CoV-2 varies. Knowledge of virus transmissibility from humans to pet rodents is important for public health to assess the potential for transmission in the home and pet breeding and selling facilities. In this study, we assessed the sensitivity of guinea pigs and gerbils to SARS-CoV-2 isolated from humans, and found that gerbils are susceptible to SARS-CoV-2, but guinea pigs are not. Pet sellers often display hamsters with high susceptibility to SARS-CoV-2 in the same area as gerbils, so caution should be exercised during COVID-19 outbreaks.https://doi.org/10.1038/s44298-024-00068-8 |
| spellingShingle | Kiyoko Iwatsuki-Horimoto Maki Kiso Mutsumi Ito Seiya Yamayoshi Yoshihiro Kawaoka Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not npj Viruses |
| title | Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not |
| title_full | Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not |
| title_fullStr | Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not |
| title_full_unstemmed | Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not |
| title_short | Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not |
| title_sort | sensitivity of rodents to sars cov 2 gerbils are susceptible to sars cov 2 but guinea pigs are not |
| url | https://doi.org/10.1038/s44298-024-00068-8 |
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