Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not

Abstract Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibi...

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Bibliographic Details
Main Authors: Kiyoko Iwatsuki-Horimoto, Maki Kiso, Mutsumi Ito, Seiya Yamayoshi, Yoshihiro Kawaoka
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-024-00068-8
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