Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay
ABSTRACT Background Malaria is a life‐threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant...
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2025-05-01
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| Online Access: | https://doi.org/10.1002/iid3.70205 |
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| author | Ganesh Bushi Mahalaqua Nazli Khatib Renuka Jyothi. S Irwanjot Kaur Abhishek Sharma Suhaib Iqbal M. Ravi Kumar Ashish Singh Chauhan Teena Vishwakarma Praveen Malik Quazi Syed Zahiruddin Mahendra Pratap Singh Muhammed Shabil Rachana Mehta Sanjit Sah Hawra Albayat Tarek Sulaiman Ali Al bshabshe Nawal A. Al Kaabi Hayam A Alrasheed Mubarak Alfaresi Amal A. Sabour Eman Alamri Maha F. Al‐Subaie Ali A. Rabaan |
| author_facet | Ganesh Bushi Mahalaqua Nazli Khatib Renuka Jyothi. S Irwanjot Kaur Abhishek Sharma Suhaib Iqbal M. Ravi Kumar Ashish Singh Chauhan Teena Vishwakarma Praveen Malik Quazi Syed Zahiruddin Mahendra Pratap Singh Muhammed Shabil Rachana Mehta Sanjit Sah Hawra Albayat Tarek Sulaiman Ali Al bshabshe Nawal A. Al Kaabi Hayam A Alrasheed Mubarak Alfaresi Amal A. Sabour Eman Alamri Maha F. Al‐Subaie Ali A. Rabaan |
| author_sort | Ganesh Bushi |
| collection | DOAJ |
| description | ABSTRACT Background Malaria is a life‐threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. This review evaluates awareness, acceptance, hesitancy, and willingness to pay (WTP) for the RTS,S/AS01 malaria vaccine, along with the key factors influencing these outcomes. Methods A comprehensive literature search was conducted in Web of Science, PubMed, and Embase, covering publications up to 18 June 2024. Observational studies assessing awareness, acceptance, hesitancy, and WTP for the malaria vaccine in endemic regions were included. Two independent reviewers screened the studies. Data extraction was performed using Nested Knowledge software and analyzed with R v.4.4. Pooled prevalences were estimated using random‐effects models, and heterogeneity was assessed with the I² statistic. Results Eighteen studies with 21,975 participants provided insights into malaria vaccine dynamics: 32% awareness (95% CI, 18%–50%), 83% acceptance (95% CI, 75%–89%), 14% hesitancy (95% CI, 7%–26%), and 58% WTP (95% CI, 34%–79%). Key determinants of acceptance included age, where younger adults (18–24 years) showed lower acceptance (OR = 0.64, 95% CI, 0.35–0.93). Employment, particularly farmers, had higher acceptance rates (OR = 3.20, 95% CI, 1.00–7.40). Lower socioeconomic status and larger family sizes were associated with decreased acceptance (OR = 0.18, 95% CI, 0.02–0.38). Conclusion This review revealed an 83% acceptance rate for the malaria vaccine, with variability in awareness (32%), hesitancy (14%), and willingness to pay (58%). Age, employment, and socioeconomic status were significant determinants of acceptance. However, due to potential publication bias and high heterogeneity, these findings should be cautiously interpreted. The results highlight the necessity for targeted interventions to enhance vaccine acceptance. Further research is required to elucidate factors that influence vaccine acceptance. |
| format | Article |
| id | doaj-art-fc02b8f5d9ee44efb51d35c3e8c66d57 |
| institution | DOAJ |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-fc02b8f5d9ee44efb51d35c3e8c66d572025-08-20T03:05:44ZengWileyImmunity, Inflammation and Disease2050-45272025-05-01135n/an/a10.1002/iid3.70205Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to PayGanesh Bushi0Mahalaqua Nazli Khatib1Renuka Jyothi. S2Irwanjot Kaur3Abhishek Sharma4Suhaib Iqbal5M. Ravi Kumar6Ashish Singh Chauhan7Teena Vishwakarma8Praveen Malik9Quazi Syed Zahiruddin10Mahendra Pratap Singh11Muhammed Shabil12Rachana Mehta13Sanjit Sah14Hawra Albayat15Tarek Sulaiman16Ali Al bshabshe17Nawal A. Al Kaabi18Hayam A Alrasheed19Mubarak Alfaresi20Amal A. Sabour21Eman Alamri22Maha F. Al‐Subaie23Ali A. Rabaan24School of Pharmaceutical Sciences Lovely Professional University Phagwara Punjab IndiaDivision of Evidence Synthessis, Global Consortium of Public Health and Research Datta Meghe Institute of Higher Education Wardha Maharashtra IndiaDepartment of Biotechnology and Genetics School of Sciences, JAIN (Deemed to be University) Bangalore Karnataka IndiaDepartment of Allied Healthcare and Sciences Vivekananda Global University Jaipur Rajasthan IndiaDepartment of Medicine NIMS University Jaipur Rajasthan IndiaChandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri Mohali Punjab IndiaDepartment of Chemistry Raghu Engineering College Visakhapatnam Andhra Pradesh IndiaDivision of Research and Innovation Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University Dehradun Uttarakhand IndiaIES Institute of Pharmacy IES University Bhopal Madhya Pradesh IndiaNew Delhi Institute of Management Delhi IndiaSouth Asia Infant Feeding Research Network, Division of Evidence Synthesis, Global Consortium of Public Health and Research Datta Meghe Institute of Higher Education Wardha Maharashtra IndiaCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai Tamil Nadu IndiaUniversity Center for Research and Development, Chandigarh University Mohali Punjab IndiaClinical Microbiology, RDC Manav Rachna International Institute of Research and Studies Faridabad Haryana IndiaDepartment of Pediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre Dr. D. Y. Patil Vidyapeeth (Deemed‐to‐be‐University), Pimpri Pune IndiaInfectious Disease Department King Saud Medical City Riyadh Saudi ArabiaInfectious Diseases Section, Medical Specialties Department King Fahad Medical City Riyadh Saudi ArabiaAdult critical care Department of medicine, Division of adult critical care, College of medicine King Khalid University Abha Saudi ArabiaCollege of Medicine and Health Science Khalifa University Abu Dhabi United Arab EmiratesDepartment of Pharmacy Practice, College of Pharmacy Princess Nourah bint Abdulrahman University Riyadh Saudi ArabiaDepartment of Microbiology National Reference Laboratory, Cleveland Clinic Abu Dhabi Abu Dhabi United Arab EmiratesDepartment of Botany and Microbiology, College of Science King Saud University Riyadh Saudi ArabiaFood Science and Nutrition, Faculty of Science University of Tabuk Tabuk Saudi ArabiaResearch Center Dr. Sulaiman Alhabib Medical Group Riyadh Saudi ArabiaCollege of Medicine Alfaisal University Riyadh Saudi ArabiaABSTRACT Background Malaria is a life‐threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. This review evaluates awareness, acceptance, hesitancy, and willingness to pay (WTP) for the RTS,S/AS01 malaria vaccine, along with the key factors influencing these outcomes. Methods A comprehensive literature search was conducted in Web of Science, PubMed, and Embase, covering publications up to 18 June 2024. Observational studies assessing awareness, acceptance, hesitancy, and WTP for the malaria vaccine in endemic regions were included. Two independent reviewers screened the studies. Data extraction was performed using Nested Knowledge software and analyzed with R v.4.4. Pooled prevalences were estimated using random‐effects models, and heterogeneity was assessed with the I² statistic. Results Eighteen studies with 21,975 participants provided insights into malaria vaccine dynamics: 32% awareness (95% CI, 18%–50%), 83% acceptance (95% CI, 75%–89%), 14% hesitancy (95% CI, 7%–26%), and 58% WTP (95% CI, 34%–79%). Key determinants of acceptance included age, where younger adults (18–24 years) showed lower acceptance (OR = 0.64, 95% CI, 0.35–0.93). Employment, particularly farmers, had higher acceptance rates (OR = 3.20, 95% CI, 1.00–7.40). Lower socioeconomic status and larger family sizes were associated with decreased acceptance (OR = 0.18, 95% CI, 0.02–0.38). Conclusion This review revealed an 83% acceptance rate for the malaria vaccine, with variability in awareness (32%), hesitancy (14%), and willingness to pay (58%). Age, employment, and socioeconomic status were significant determinants of acceptance. However, due to potential publication bias and high heterogeneity, these findings should be cautiously interpreted. The results highlight the necessity for targeted interventions to enhance vaccine acceptance. Further research is required to elucidate factors that influence vaccine acceptance.https://doi.org/10.1002/iid3.70205acceptanceawarenesshesitancymalaria vaccinesystematic reviewwillingness to pay |
| spellingShingle | Ganesh Bushi Mahalaqua Nazli Khatib Renuka Jyothi. S Irwanjot Kaur Abhishek Sharma Suhaib Iqbal M. Ravi Kumar Ashish Singh Chauhan Teena Vishwakarma Praveen Malik Quazi Syed Zahiruddin Mahendra Pratap Singh Muhammed Shabil Rachana Mehta Sanjit Sah Hawra Albayat Tarek Sulaiman Ali Al bshabshe Nawal A. Al Kaabi Hayam A Alrasheed Mubarak Alfaresi Amal A. Sabour Eman Alamri Maha F. Al‐Subaie Ali A. Rabaan Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay Immunity, Inflammation and Disease acceptance awareness hesitancy malaria vaccine systematic review willingness to pay |
| title | Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay |
| title_full | Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay |
| title_fullStr | Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay |
| title_full_unstemmed | Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay |
| title_short | Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay |
| title_sort | determinants of malaria vaccine acceptance a systematic review and meta analysis of awareness acceptance hesitancy and willingness to pay |
| topic | acceptance awareness hesitancy malaria vaccine systematic review willingness to pay |
| url | https://doi.org/10.1002/iid3.70205 |
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